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Table 4 Size of tests for gene-gene interactions under the various values of M D

From: Jackknife-based gene-gene interaction tests for untyped SNPs

M D of marker G

WTT

WTT c

Truth/ WTT

Truth/ WTT c

0.0235

0.008

0.006

0.006

0.006

0.2222

0.016

0.008

0.010

0.009

0.3528

0.011

0.006

0.007

0.005

0.6057

0.011

0.006

0.010

0.008

1

0.007

0.004

0.010

0.008

  1. WTT corresponds to test (5). WTT c corresponds to test (6). Truth/WTT and Truth/ WTT c are test (4) and ICPT on true genotypes, respectively. The values of M D for marker G range from 0.0235 to 1 while the value of M D for marker H is fixed as 0.7615. Number of individuals in cases is 5000. Significance level =0.01. WTT, Wald-type test; WTT c , Wald-type test with constraints