Table 2 Genotype distributions, minor allele frequencies, and unadjusted p-values for comparing genotype distributions according to diabetes status and gender
From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans
No diabetes | Diabetes | p-value | Men | Women | p-value | Overall | |
|---|---|---|---|---|---|---|---|
N | 620 | 239 | 195 | 664 | 859 | ||
rs60910145 | |||||||
T/T, n (%) | 582 (93.9) | 220 (92.0) | 0.355 | 179 (91.8) | 623 (93.8) | 0.380 | 802 (93.4) |
T/G, n (%) | 36 (5.8) | 19 (7.9) | 16 (8.2) | 39 (5.9) | 55 (6.4) | ||
G/G, n (%) | 2 (0.3) | 0 (0) | 0 (0) | 2 (0.3) | 2 (0.2) | ||
G, n (%) | 40 (3.2) | 19 (4.0) | 0.446 | 16 (4.1) | 43 (3.2) | 0.410 | 59 (3.4) |
HWE (p-value) | 0.127 | >0.999 | >0.999 | 0.145 | 0.263 | ||
rs73885319 | |||||||
A/A, n (%) | 580 (93.5) | 219 (91.6) | 0.346 | 179 (91.8) | 620 (93.4) | 0.492 | 799 (93.0) |
A/G, n (%) | 38 (6.1) | 20 (8.4) | 16 (8.2) | 42 (6.3) | 58 (6.7) | ||
G/G, n (%) | 2 (0.3) | 0 (0) | 0 (0) | 2 (0.3) | 2 (0.2) | ||
G, n (%) | 42 (3.4) | 20 (4.2) | 0.427 | 16 (4.1) | 46 (3.5) | 0.554 | 62 (3.6) |
HWE (p-value) | 0.150 | >0.999 | >0.999 | 0.181 | 0.302 | ||
rs71785313 | |||||||
TTATTA / TTATTA, n (%) | 555 (89.5) | 210 (87.9) | 0.704 | 181 (92.8) | 584 (87.9) | 0.154 | 765 (89.1) |
TTATTA /Del, n (%) | 62 (10.0) | 27 (11.3) | 13 (6.7) | 76 (11.4) | 89 (10.4) | ||
Del/Del, n (%) | 3 (0.5) | 2 (0.8) | 1 (0.5) | 4 (0.6) | 5 (0.6) | ||
Del, n (%) | 68 (11.0) | 31 (6.5) | 0.424 | 15 (3.8) | 84 (6.3) | 0.065 | 99 (5.8) |
HWE (p-value) | 0.420 | 0.253 | 0.244 | 0.324 | 0.195 | ||