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Table 2 Genotype distributions, minor allele frequencies, and unadjusted p-values for comparing genotype distributions according to diabetes status and gender

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

  No diabetes Diabetes p-value Men Women p-value Overall
N 620 239   195 664   859
rs60910145       
T/T, n (%) 582 (93.9) 220 (92.0) 0.355 179 (91.8) 623 (93.8) 0.380 802 (93.4)
T/G, n (%) 36 (5.8) 19 (7.9)   16 (8.2) 39 (5.9)   55 (6.4)
G/G, n (%) 2 (0.3) 0 (0)   0 (0) 2 (0.3)   2 (0.2)
G, n (%) 40 (3.2) 19 (4.0) 0.446 16 (4.1) 43 (3.2) 0.410 59 (3.4)
HWE (p-value) 0.127 >0.999   >0.999 0.145   0.263
rs73885319       
A/A, n (%) 580 (93.5) 219 (91.6) 0.346 179 (91.8) 620 (93.4) 0.492 799 (93.0)
A/G, n (%) 38 (6.1) 20 (8.4)   16 (8.2) 42 (6.3)   58 (6.7)
G/G, n (%) 2 (0.3) 0 (0)   0 (0) 2 (0.3)   2 (0.2)
G, n (%) 42 (3.4) 20 (4.2) 0.427 16 (4.1) 46 (3.5) 0.554 62 (3.6)
HWE (p-value) 0.150 >0.999   >0.999 0.181   0.302
rs71785313        
TTATTA / TTATTA, n (%) 555 (89.5) 210 (87.9) 0.704 181 (92.8) 584 (87.9) 0.154 765 (89.1)
TTATTA /Del, n (%) 62 (10.0) 27 (11.3)   13 (6.7) 76 (11.4)   89 (10.4)
Del/Del, n (%) 3 (0.5) 2 (0.8)   1 (0.5) 4 (0.6)   5 (0.6)
Del, n (%) 68 (11.0) 31 (6.5) 0.424 15 (3.8) 84 (6.3) 0.065 99 (5.8)
HWE (p-value) 0.420 0.253   0.244 0.324   0.195
  1. HWE, Hardy-Weinberg Equilibrium (HWE p-values are from exact tests)