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Table 3 Baseline characteristics by allele combination

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

Characteristics 0 risk allele One risk allele Two risk alleles P-value* p-value**
N 707 143 9   
Gender, men n (%) 166 (23.5) 27 (18.8) 2 (22.2) 0.488 0.972
Mean age, years (SD) 53.2 (14.0) 52.7 (10.0) 54.3 (10.2) 0.902 0.797
Mean BMI, kg/m2 (SD) 30.0 (7.5) 30.0 (6.7) 32.0 (6.9) 0.722 0.420
Mean WHR (SD) 0.88 (0.10) 0.89 (0.08) 0.92 (0.11) 0.484 0.266
Mean SBP, mmHg (SD) 123 (20) 127 (23) 121 (12) 0.113 0.737
Mean DBP, mmHg (SD) 75 (12) 77 (13) 75 (12) 0.117 0.884
Hypertension, yes (%) 466 (65.9) 98 (68.5) 8 (88.9) 0.301 0.118
Mean HbA1c, % (SD) 6.2 (1.4) 6.5 (1.7) 6.6 (1.5) 0.154 0.586
Mean FBG, mmol/l (SD) 6.3 (3.0) 6.9 (3.6) 7.0 (3.3) 0.140 0.599
Mean 2-h glucose, mmol/l (SD) 7.4 (3.2) 8.2 (4.7) 9.0 (4.2) 0.040 0.264
Median urine creatinine, mmol/l (25th-75th percentiles) 7.9 [5.2-11.8] 7.9 [4.5-12.1] 5.6 [5.5-8.8] 0.664 0.466
Median urine Microalbumin, mg/l (25th-75th percentiles) 4.4 [3.0-11.4] 4.3 [3.0-11.7] 3.0 [3.0-7.3] 0.537 0.293
Median ACR, mg/mmol (25th-75th percentiles) 0.75 [0.41-1.61] 0.77 [0.41-1.50] 0.54 [0.34-1.06] 0.876 0.541
Median serum creatinine,μmol/l (25th-75th percentiles) 80 [69-92] 79 [69-90] 85 [82-92] 0.254 0.244
Median eGFR (MDRD), ml/min (SD) 85.9 [70.8-102.2] 84.2 [73.9-99.1] 76.6 [73.6-81.0] 0.258 0.147
eGFR (MDRD) <60, n (%) 67 (9.5) 11 (7.7) 1 (11.1) 0.781 0.846
Median eGFR (CKD-EPI), ml/min (SD) 91.8 [72.0-109.9] 91.2 [75.2-107.9] 82.2 [77.1-85.2] 0.275 0.160
eGFR (CKD-EPI) <60, n (%) 60 (8.5) 12 (8.4) 1 (11.1) 0.960 0.786
  1. ACR, urinary albumin/creatinine ratio; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; SD, standard deviation
  2. *p-values from chi square, ANOVA and Kruskal-Wallis tests
  3. **p-values from recessive genetic models