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Table 5 Generalized linear and logistic regression models showing the effects of genes on kidney functions and other continuous predictors (dominant model)

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

   Overall Interaction p for the gene and
Allele Phenotype Effects size (95 % CI) P Sex diabetes hypertension
rs60910145 T/G-G/G Serum creatinine (loge[μmol/l]) −0.029 (-0.084 to 0.026) 0.307 0.658 0.176 0.158
  eGFR (MDRD) [ml/min] 2.09 (-3.73 to 7.91) 0.482 0.444 0.199 0.101
  eGFR (CKD-EPI) [ml/min] 3.24 (-1.57 to 8.06) 0.187 0.768 0.143 0.103
  Prevalent CKD (MDRD) 0.59 (0.18 to 1.89) 0.350 0.677 0.081 0.410
  Prevalent CKD (CKD-EPI) 0.84 (0.27 to 2.65) 0.767 0.244 0.118 0.456
  Albumin/creatinine ratio (loge[mg/mmol]) −0.154 (-0.502 to 0.193) 0.384 0.331 0.947 0.525
  Systolic blood pressure (mmHg) −0.02 (-5.31 to 5.27) 0.993 0.839 0.536 0.963
rs73885319 A/G-G/G Serum creatinine (loge[μmol/l]) −0.026 (-0.080 to 0.028) 0.341 0.612 0.260 0.273
  eGFR (MDRD) [ml/min] 1.75 (-3.93 to 7.44) 0.546 0.402 0.283 0.181
  eGFR (CKD-EPI) [ml/min] 2.96 (-1.74 to 7.66) 0.217 0.708 0.233 0.264
  Prevalent CKD (MDRD) 0.56 (0.18 to 1.79) 0.307 0.654 0.086 0.411
  Prevalent CKD (CKD-EPI) 0.81 (0.26 to 2.54) 0.720 0.233 0.123 0.455
  Albumin/creatinine ratio (loge[mg/mmol]) −0.096 (-0.436 to 0.245) 0.583 0.240 0.883 0.411
  Systolic blood pressure (mmHg) −0.020 (-5.18 to 5.14) 0.994 0.834 0.585 0.837
rs71785313 TTATTA /Del-Del/Del Serum creatinine (loge[μmol/l]) 0.020 (-0.024 to 0.064) 0.382 0.549 0.801 0.891
  eGFR (MDRD) [ml/min] −2.35 (-6.99 to 2.30) 0.323 0.479 0.865 0.893
  eGFR (CKD-EPI) [ml/min] −3.03 (-6.88 to 0.81) 0.123 0.478 0.815 0.988
  Prevalent CKD (MDRD) 0.91 (0.38 to 2.14) 0.823 0.934 0.639 0.782
  Prevalent CKD (CKD-EPI) 1.07 (0.43 to 2.66) 0.890 0.971 0.487 0.622
  Albumin/creatinine ratio (loge[mg/mmol]) 0.050 (-0.214 to 0.314) 0.710 0.587 0.854 0.889
  Systolic blood pressure (mmHg) 5.60 (1.39 to 9.80) 0.009 0.892 0.025 0.593
  1. Models are adjusted for age, sex, diabetes status and hypertension
  2. Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits
  3. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease