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Table 6 Generalized linear and logistic regression models showing the effects of genes on kidney functions and other continuous predictors (additive model)

From: APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans

   Overall
Allele Phenotype Effects size (95%CI) P
rs60910145 G Serum creatinine (loge[μmol/l]) −0.020 (-0.072 to 0.033) 0.466
  eGFR (MDRD) [ml/min] 1.26 (-4.27 to 6.79) 0.656
  eGFR (CKD-EPI) [ml/min] 2.28 (-2.29 to 6.86) 0.328
  Prevalent CKD (MDRD) 0.80 (0.28 to 2.27) 0.665
  Prevalent CKD (CKD-EPI) 1.12 (0.39 to 3.16) 0.836
  Albumin/creatinine ratio (loge[mg/mmol]) −0.178 (-0.504 to 0.147) 0.283
  Systolic blood pressure (mmHg) −0.03 (-5.06 to 4.99) 0.989
rs73885319 G Serum creatinine (loge[μmol/l]) −0.018 (-0.069 to 0.034) 0.503
  eGFR (MDRD) [ml/min] 0.99 (-4.42 to 6.40) 0.720
  eGFR (CKD-EPI) [ml/min] 2.07 (-2.40 to 6.55) 0.364
  Prevalent CKD (MDRD) 0.76 (0.27 to 2.16) 0.601
  Prevalent CKD (CKD-EPI) 1.08 (0.38 to 3.03) 0.887
  Albumin/creatinine ratio (loge[mg/mmol]) −0.126 (-0.446 to 0.195) 0.442
  Systolic blood pressure (mmHg) −0.03 (-4.95 to 4.89) 0.990
rs71785313 Del Serum creatinine (loge[μmol/l]) 0.019 (-0.022 to 0.060) 0.367
  eGFR (MDRD) [ml/min] −2.38 (-6.68 to 1.93) 0.323
  eGFR (CKD-EPI) [ml/min] −2.91 (-6.46 to 0.65) 0.110
  Prevalent CKD (MDRD) 0.86 (0.39 8to 1.93) 0.712
  Prevalent CKD (CKD-EPI) 1.00 (0.42 to 2.34) 0.993
  Albumin/creatinine ratio (loge[mg/mmol]) 0.035 (-0.207 to 0.277) 0.777
  Systolic blood pressure (mmHg) 4.48 (0.58 to 8.38) 0.025
  1. Models are adjusted for age, sex, diabetes status and hypertension
  2. Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease