Table 2 Relationship between miRNA and CAV1 and CAV2 in health and disease
From: Epigenetic modifications of caveolae associated proteins in health and disease
miRNA | Target caveolae related gene | Changes observed and involvement in health and diseases |
|---|---|---|
miRNA-133a | CAV1 | miRNA-133a is up-regulated in head and neck squamous cell carcinoma and down-regulates CAV1 [86] |
miRNA-802 | CAV1 | miRNA-802 is increased and up-regulates potassium channel expression in kidney by down-regulating CAV1 [87] |
miRNA-103 | CAV1 | miRNA-103 is up-regulated in obese animals and associated with impaired glucose homeostasis by down-regulating CAV1 [88] |
miRNA-107 | CAV1 | miRNA-107 is up-regulated in obese animals and associated with impaired glucose homeostasis down-regulating CAV1 [88] |
miRNA-199a-5p | CAV1 | miRNA-199a-5p is over-expressed in tissue fibrosis and pre-adipocytes, affects tissue fibrosis and proliferation of pre-adipocytes [91, 90] |
miRNA-124 | CAV1 | miRNA-124 down-regulates CAV1 and caveolae to prevent uptake of pathogens in kidney cells [93] |
miRNA-192 | CAV1 | Exposure to DHA up-regulates miRNA-192 and down-regulates CAV1 [94] |
miRNA-199a-3p | CAV2 | miRNA-199a-3p is up-regulated in breast cancer and down-regulates CAV2 [95] |
miRNA-218 | CAV2 | miRNA-128 is down-regulated in renal cell carcinoma and up-regulates CAV2 [96] |
miRNA-29a | CAV2 | miRNA-29a is up-regulated following Salmonella infection and down-regulates CAV2 [97] |