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Table 2 Relationship between miRNA and CAV1 and CAV2 in health and disease

From: Epigenetic modifications of caveolae associated proteins in health and disease

miRNA Target caveolae related gene Changes observed and involvement in health and diseases
miRNA-133a CAV1 miRNA-133a is up-regulated in head and neck squamous cell carcinoma and down-regulates CAV1 [86]
miRNA-802 CAV1 miRNA-802 is increased and up-regulates potassium channel expression in kidney by down-regulating CAV1 [87]
miRNA-103 CAV1 miRNA-103 is up-regulated in obese animals and associated with impaired glucose homeostasis by down-regulating CAV1 [88]
miRNA-107 CAV1 miRNA-107 is up-regulated in obese animals and associated with impaired glucose homeostasis down-regulating CAV1 [88]
miRNA-199a-5p CAV1 miRNA-199a-5p is over-expressed in tissue fibrosis and pre-adipocytes, affects tissue fibrosis and proliferation of pre-adipocytes [91, 90]
miRNA-124 CAV1 miRNA-124 down-regulates CAV1 and caveolae to prevent uptake of pathogens in kidney cells [93]
miRNA-192 CAV1 Exposure to DHA up-regulates miRNA-192 and down-regulates CAV1 [94]
miRNA-199a-3p CAV2 miRNA-199a-3p is up-regulated in breast cancer and down-regulates CAV2 [95]
miRNA-218 CAV2 miRNA-128 is down-regulated in renal cell carcinoma and up-regulates CAV2 [96]
miRNA-29a CAV2 miRNA-29a is up-regulated following Salmonella infection and down-regulates CAV2 [97]