Table 2 Significant variants in Uygur compared to the 11 populations, as determined by Chi-square test
SNP ID | Genes | Chi-square test p value | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CHB | JPT | CEU | YRI | ASW | CHD | GIF | LWK | MEX | MKK | TSI | ||
rs1801131 | MTHFR | 2.64E-01 | 5.50E-02 | 5.61E-01 | 4.64E-05 | 1.28E-01 | 1.28E-01 | 1.23E-01 | 5.13E-02 | 3.21E-01 | 6.99E-01 | 4.68E-01 |
rs1801133 | MTHFR | 5.56E-02 | 8.61E-01 | 6.49E-01 | 5.64E-09 | 6.93E-06 | 9.87E-01 | 6.81E-04 | 4.89E-08 | 4.45E-01 | 4.97E-11 | 7.77E-02 |
rs6025 | F5 | - | - | 5.47E-01 | - | - | - | - | - | - | - | - |
rs20417 | PTGS2 | 2.27E-30 | 3.82E-30 | 1.42E-30 | 3.59E-25 | - | - | - | - | - | - | - |
rs689466 | PTGS2 | 1.58E-04 | 9.82E-03 | 1.79E-02 | 8.07E-06 | 2.72E-03 | 3.17E-03 | 1.18E-02 | 4.71E-09 | 6.02E-01 | 6.96E-13 | 3.42E-02 |
rs4124874 | UGT1A1 | 5.43E-04 | 2.54E-02 | 8.95E-01 | 1.45E-18 | 6.07E-06 | 2.73E-02 | 1.58E-02 | 2.31E-14 | 6.95E-01 | 8.73E-14 | 5.94E-01 |
rs10929302 | UGT1A1 | 1.27E-02 | 1.55E-02 | 7.21E-01 | 2.68E-02 | - | - | - | - | - | - | - |
rs4148323 | UGT1A1 | 1.00E-02 | 8.23E-01 | 3.34E-04 | 3.34E-04 | - | 4.91E-01 | 1.52E-03 | - | 4.21E-02 | - | - |
rs7626962 | SCN5A | - | - | - | 1.61E-03 | - | - | - | - | - | - | - |
rs1805124 | SCN5A | 5.41E-02 | 1.67E-01 | 7.66E-01 | 3.09E-02 | 3.68E-01 | 7.42E-03 | 9.77E-01 | 1.04E-01 | 5.81E-01 | 1.01E-03 | 4.23E-01 |
rs3814055 | NR1I2 | 2.86E-01 | 1.37E-01 | 8.69E-01 | 1.21E-01 | 7.00E-01 | 7.20E-02 | 4.08E-01 | 2.75E-01 | 2.51E-01 | 8.66E-04 | 8.24E-01 |
rs2046934 | P2RY12 | 6.84E-01 | 6.10E-01 | 2.60E-01 | 2.50E-01 | - | - | - | - | - | - | - |
rs701265 | P2RY1 | 2.09E-01 | 5.56E-01 | 6.25E-01 | 2.75E-23 | 7.57E-11 | 4.26E-01 | 2.11E-01 | 4.41E-21 | 8.25E-01 | 1.87E-23 | 4.24E-01 |
rs975833 | ADH1A | 7.76E-11 | 3.63E-09 | 2.56E-01 | 2.56E-01 | - | - | - | - | - | - | - |
rs2066702 | ADH1B | - | - | - | 1.70E-14 | 2.43E-10 | - | - | 7.05E-07 | - | - | - |
rs1229984 | ADH1B | 4.84E-10 | 6.69E-09 | 1.28E-11 | 1.79E-11 | - | - | - | - | - | - | - |
rs698 | ADH1C | 2.29E-04 | 4.26E-04 | 5.04E-08 | 1.35E-04 | 5.01E-02 | 3.58E-03 | 2.41E-01 | 3.71E-01 | 5.69E-01 | 4.18E-01 | 2.40E-02 |
rs3846662 | HMGCR | 7.31E-01 | 9.72E-01 | 6.50E-02 | 1.61E-21 | 1.18E-08 | 6.07E-01 | 3.68E-02 | 8.13E-20 | 2.60E-02 | 2.51E-12 | 1.88E-01 |
rs1042713 | ADRB2 | 5.37E-01 | 2.62E-01 | 7.49E-03 | 2.31E-01 | 4.76E-01 | 3.59E-01 | 1.81E-01 | 5.87E-01 | 6.38E-01 | 6.13E-01 | 2.35E-03 |
rs1042714 | ADRB2 | 6.84E-01 | 7.77E-02 | 5.86E-08 | 3.04E-01 | - | - | - | - | - | - | - |
rs1142345 | TPMT | - | - | - | 6.38E-02 | - | - | - | 5.08E-05 | 4.66E-03 | 7.52E-52 | - |
rs2066853 | AHR | 6.40E-04 | 9.34E-06 | 5.30E-03 | 1.34E-05 | 2.98E-03 | 2.09E-03 | 2.84E-02 | 5.09E-07 | 1.08E-01 | 1.26E-03 | 3.22E-03 |
rs1045642 | ABCB1 | 8.23E-03 | 3.13E-02 | 3.10E-01 | 3.16E-18 | 7.87E-08 | 1.84E-04 | 9.12E-01 | - | 1.07E-01 | 4.28E-17 | 1.33E-01 |
rs2032582 | ABCB1 | 8.02E-01 | 3.09E-01 | 9.05E-03 | - | 1.06E-14 | 3.95E-02 | - | - | - | - | - |
rs2032582 | ABCB1 | - | - | - | - | 1.49E-01 | 1.77E-04 | - | - | - | - | - |
rs2032582 | ABCB1 | - | - | - | - | 1.23E-16 | 1.51E-10 | - | - | - | - | - |
rs1128503 | ABCB1 | 7.10E-01 | 2.93E-01 | 1.73E-05 | 1.63E-22 | 4.13E-12 | 7.84E-01 | 2.67E-01 | 1.51E-20 | 2.52E-03 | 5.63E-23 | 6.23E-05 |
rs10264272 | CYP3A5 | - | - | - | 1.76E-08 | - | - | - | 3.72E-12 | - | 1.61E-07 | - |
rs776746 | CYP3A5 | 4.82E-13 | 1.37E-12 | 5.51E-02 | 1.56E-43 | 9.11E-27 | 2.09E-10 | 1.04E-10 | 9.92E-38 | 3.17E-11 | 2.71E-28 | 1.52E-02 |
rs3815459 | KCNH2 | 4.49E-02 | 6.90E-04 | - | 2.69E-03 | - | - | - | - | - | - | - |
rs3807375 | KCNH2 | 9.10E-04 | 8.15E-08 | 8.52E-03 | 2.75E-07 | 1.82E-02 | 5.77E-04 | 1.94E-02 | 3.81E-07 | 6.07E-01 | 1.36E-05 | 2.76E-03 |
rs4244285 | CYP2C19 | 7.60E-03 | 7.79E-02 | 7.63E-01 | 8.20E-01 | - | - | - | - | - | - | - |
rs1801252 | ADRB1 | 3.99E-04 | 4.69E-04 | - | 1.77E-04 | - | - | - | - | - | - | - |
rs1801253 | ADRB1 | 4.01E-01 | 5.97E-01 | 4.11E-02 | 1.39E-04 | - | - | - | - | - | - | - |
rs1695 | GSTP1 | 1.97E-02 | 5.30E-06 | 4.87E-02 | 2.14E-01 | 5.59E-02 | 3.14E-02 | 5.37E-01 | 2.61E-04 | 1.46E-03 | 5.49E-01 | 5.90E-01 |
rs1138272 | GSTP1 | - | - | - | - | - | - | - | - | 3.82E-01 | - | - |
rs1800497 | ANKK1 | 5.75E-03 | 7.02E-03 | 4.03E-01 | 2.26E-03 | 3.61E-02 | 1.02E-03 | 9.04E-01 | 4.19E-02 | 7.81E-03 | 3.21E-02 | 5.35E-01 |
rs6277 | DRD2 | 7.51E-07 | 9.21E-07 | 2.73E-03 | 1.15E-09 | - | - | - | - | - | - | - |
rs4149056 | SLCO1B1 | 3.90E-01 | 2.55E-01 | 3.73E-01 | - | 3.47E-02 | 3.12E-01 | - | - | - | 4.92E-01 | 1.43E-02 |
rs7975232 | VDR | 3.64E-01 | 5.13E-01 | 2.26E-03 | 7.99E-06 | 3.56E-04 | 2.20E-01 | 7.13E-03 | 5.31E-09 | 5.87E-02 | 8.30E-09 | 7.35E-04 |
rs1544410 | VDR | 7.55E-08 | 2.36E-03 | 6.90E-04 | 8.50E-01 | 2.39E-01 | 5.95E-08 | 3.45E-03 | 9.28E-01 | 9.17E-01 | 3.44E-02 | 6.49E-03 |
rs2239185 | VDR | 2.76E-01 | 3.57E-01 | - | 4.96E-02 | - | - | - | - | - | - | - |
rs1540339 | VDR | 4.18E-04 | 7.39E-05 | 2.87E-02 | 2.34E-08 | 2.07E-04 | 2.63E-05 | 1.43E-02 | 3.95E-11 | 2.23E-01 | 7.15E-11 | 2.40E-02 |
rs2239179 | VDR | 1.49E-02 | 4.20E-03 | 3.05E-02 | 1.57E-01 | 1.22E-01 | 4.13E-03 | 7.35E-02 | 7.84E-01 | 2.95E-01 | 4.02E-01 | 7.32E-01 |
rs3782905 | VDR | 3.53E-13 | 2.82E-17 | 1.09E-10 | 2.88E-14 | - | - | - | - | - | - | - |
rs10735810 | VDR | 1.61E-01 | 1.87E-01 | 9.34E-02 | 1.81E-02 | 4.22E-02 | 4.66E-03 | 5.86E-01 | 1.58E-03 | 2.77E-03 | 1.90E-02 | 2.90E-01 |
rs11568820 | VDR | 1.28E-01 | 8.00E-02 | 6.18E-03 | 1.16E-31 | 5.41E-08 | 8.53E-01 | 3.03E-01 | 3.47E-19 | 3.45E-02 | 6.79E-17 | 7.59E-02 |
rs7294 | VKORC1 | 4.64E-08 | 2.30E-05 | 3.77E-01 | 5.06E-05 | 2.06E-03 | 7.51E-07 | 1.38E-12 | 1.46E-02 | 7.81E-01 | 1.90E-04 | 3.15E-01 |
rs9934438 | VKORC1 | 3.05E-12 | 2.10E-09 | 4.69E-03 | 2.89E-26 | 1.19E-11 | 2.46E-11 | 4.83E-11 | 9.77E-19 | 1.61E-01 | 3.19E-16 | 9.26E-02 |
rs1801272 | CYP2A6 | - | 1.08E-30 | 3.63E-34 | - | - | - | - | - | - | - | - |
rs3745274 | CYP2B6 | 3.21E-01 | 2.23E-01 | 1.95E-01 | 2.27E-05 | 2.73E-01 | 1.80E-01 | 6.90E-05 | 3.31E-02 | 2.34E-01 | 4.15E-04 | 1.30E-01 |
rs28399499 | CYP2B6 | - | - | - | 3.33E-06 | 4.73E-04 | - | - | - | - | 1.80E-01 | - |
rs1051266 | SLC19A1 | 8.64E-03 | 2.37E-03 | 4.08E-01 | 3.20E-09 | 2.10E-01 | 2.71E-01 | 4.03E-01 | 3.44E-10 | 3.83E-02 | 1.97E-14 | 4.33E-02 |
rs4680 | COMT | 4.53E-02 | 8.67E-03 | 5.32E-01 | 1.75E-02 | 1.64E-02 | 2.29E-03 | 9.75E-01 | 5.38E-02 | 6.03E-01 | 3.36E-03 | 3.41E-01 |