Skip to main content

Advertisement

Table 2 Significant variants in Uygur compared to the 11 populations, as determined by Chi-square test

From: Genetic polymorphisms of pharmacogenomic VIP variants in the Uygur population from northwestern China

SNP ID Genes Chi-square test p value
CHB JPT CEU YRI ASW CHD GIF LWK MEX MKK TSI
rs1801131 MTHFR 2.64E-01 5.50E-02 5.61E-01 4.64E-05 1.28E-01 1.28E-01 1.23E-01 5.13E-02 3.21E-01 6.99E-01 4.68E-01
rs1801133 MTHFR 5.56E-02 8.61E-01 6.49E-01 5.64E-09 6.93E-06 9.87E-01 6.81E-04 4.89E-08 4.45E-01 4.97E-11 7.77E-02
rs6025 F5 - - 5.47E-01 - - - - - - - -
rs20417 PTGS2 2.27E-30 3.82E-30 1.42E-30 3.59E-25 - - - - - - -
rs689466 PTGS2 1.58E-04 9.82E-03 1.79E-02 8.07E-06 2.72E-03 3.17E-03 1.18E-02 4.71E-09 6.02E-01 6.96E-13 3.42E-02
rs4124874 UGT1A1 5.43E-04 2.54E-02 8.95E-01 1.45E-18 6.07E-06 2.73E-02 1.58E-02 2.31E-14 6.95E-01 8.73E-14 5.94E-01
rs10929302 UGT1A1 1.27E-02 1.55E-02 7.21E-01 2.68E-02 - - - - - - -
rs4148323 UGT1A1 1.00E-02 8.23E-01 3.34E-04 3.34E-04 - 4.91E-01 1.52E-03 - 4.21E-02 - -
rs7626962 SCN5A - - - 1.61E-03 - - - - - - -
rs1805124 SCN5A 5.41E-02 1.67E-01 7.66E-01 3.09E-02 3.68E-01 7.42E-03 9.77E-01 1.04E-01 5.81E-01 1.01E-03 4.23E-01
rs3814055 NR1I2 2.86E-01 1.37E-01 8.69E-01 1.21E-01 7.00E-01 7.20E-02 4.08E-01 2.75E-01 2.51E-01 8.66E-04 8.24E-01
rs2046934 P2RY12 6.84E-01 6.10E-01 2.60E-01 2.50E-01 - - - - - - -
rs701265 P2RY1 2.09E-01 5.56E-01 6.25E-01 2.75E-23 7.57E-11 4.26E-01 2.11E-01 4.41E-21 8.25E-01 1.87E-23 4.24E-01
rs975833 ADH1A 7.76E-11 3.63E-09 2.56E-01 2.56E-01 - - - - - - -
rs2066702 ADH1B - - - 1.70E-14 2.43E-10 - - 7.05E-07 - - -
rs1229984 ADH1B 4.84E-10 6.69E-09 1.28E-11 1.79E-11 - - - - - - -
rs698 ADH1C 2.29E-04 4.26E-04 5.04E-08 1.35E-04 5.01E-02 3.58E-03 2.41E-01 3.71E-01 5.69E-01 4.18E-01 2.40E-02
rs3846662 HMGCR 7.31E-01 9.72E-01 6.50E-02 1.61E-21 1.18E-08 6.07E-01 3.68E-02 8.13E-20 2.60E-02 2.51E-12 1.88E-01
rs1042713 ADRB2 5.37E-01 2.62E-01 7.49E-03 2.31E-01 4.76E-01 3.59E-01 1.81E-01 5.87E-01 6.38E-01 6.13E-01 2.35E-03
rs1042714 ADRB2 6.84E-01 7.77E-02 5.86E-08 3.04E-01 - - - - - - -
rs1142345 TPMT - - - 6.38E-02 - - - 5.08E-05 4.66E-03 7.52E-52 -
rs2066853 AHR 6.40E-04 9.34E-06 5.30E-03 1.34E-05 2.98E-03 2.09E-03 2.84E-02 5.09E-07 1.08E-01 1.26E-03 3.22E-03
rs1045642 ABCB1 8.23E-03 3.13E-02 3.10E-01 3.16E-18 7.87E-08 1.84E-04 9.12E-01 - 1.07E-01 4.28E-17 1.33E-01
rs2032582 ABCB1 8.02E-01 3.09E-01 9.05E-03 - 1.06E-14 3.95E-02 - - - - -
rs2032582 ABCB1 - - - - 1.49E-01 1.77E-04 - - - - -
rs2032582 ABCB1 - - - - 1.23E-16 1.51E-10 - - - - -
rs1128503 ABCB1 7.10E-01 2.93E-01 1.73E-05 1.63E-22 4.13E-12 7.84E-01 2.67E-01 1.51E-20 2.52E-03 5.63E-23 6.23E-05
rs10264272 CYP3A5 - - - 1.76E-08 - - - 3.72E-12 - 1.61E-07 -
rs776746 CYP3A5 4.82E-13 1.37E-12 5.51E-02 1.56E-43 9.11E-27 2.09E-10 1.04E-10 9.92E-38 3.17E-11 2.71E-28 1.52E-02
rs3815459 KCNH2 4.49E-02 6.90E-04 - 2.69E-03 - - - - - - -
rs3807375 KCNH2 9.10E-04 8.15E-08 8.52E-03 2.75E-07 1.82E-02 5.77E-04 1.94E-02 3.81E-07 6.07E-01 1.36E-05 2.76E-03
rs4244285 CYP2C19 7.60E-03 7.79E-02 7.63E-01 8.20E-01 - - - - - - -
rs1801252 ADRB1 3.99E-04 4.69E-04 - 1.77E-04 - - - - - - -
rs1801253 ADRB1 4.01E-01 5.97E-01 4.11E-02 1.39E-04 - - - - - - -
rs1695 GSTP1 1.97E-02 5.30E-06 4.87E-02 2.14E-01 5.59E-02 3.14E-02 5.37E-01 2.61E-04 1.46E-03 5.49E-01 5.90E-01
rs1138272 GSTP1 - - - - - - - - 3.82E-01 - -
rs1800497 ANKK1 5.75E-03 7.02E-03 4.03E-01 2.26E-03 3.61E-02 1.02E-03 9.04E-01 4.19E-02 7.81E-03 3.21E-02 5.35E-01
rs6277 DRD2 7.51E-07 9.21E-07 2.73E-03 1.15E-09 - - - - - - -
rs4149056 SLCO1B1 3.90E-01 2.55E-01 3.73E-01 - 3.47E-02 3.12E-01 - - - 4.92E-01 1.43E-02
rs7975232 VDR 3.64E-01 5.13E-01 2.26E-03 7.99E-06 3.56E-04 2.20E-01 7.13E-03 5.31E-09 5.87E-02 8.30E-09 7.35E-04
rs1544410 VDR 7.55E-08 2.36E-03 6.90E-04 8.50E-01 2.39E-01 5.95E-08 3.45E-03 9.28E-01 9.17E-01 3.44E-02 6.49E-03
rs2239185 VDR 2.76E-01 3.57E-01 - 4.96E-02 - - - - - - -
rs1540339 VDR 4.18E-04 7.39E-05 2.87E-02 2.34E-08 2.07E-04 2.63E-05 1.43E-02 3.95E-11 2.23E-01 7.15E-11 2.40E-02
rs2239179 VDR 1.49E-02 4.20E-03 3.05E-02 1.57E-01 1.22E-01 4.13E-03 7.35E-02 7.84E-01 2.95E-01 4.02E-01 7.32E-01
rs3782905 VDR 3.53E-13 2.82E-17 1.09E-10 2.88E-14 - - - - - - -
rs10735810 VDR 1.61E-01 1.87E-01 9.34E-02 1.81E-02 4.22E-02 4.66E-03 5.86E-01 1.58E-03 2.77E-03 1.90E-02 2.90E-01
rs11568820 VDR 1.28E-01 8.00E-02 6.18E-03 1.16E-31 5.41E-08 8.53E-01 3.03E-01 3.47E-19 3.45E-02 6.79E-17 7.59E-02
rs7294 VKORC1 4.64E-08 2.30E-05 3.77E-01 5.06E-05 2.06E-03 7.51E-07 1.38E-12 1.46E-02 7.81E-01 1.90E-04 3.15E-01
rs9934438 VKORC1 3.05E-12 2.10E-09 4.69E-03 2.89E-26 1.19E-11 2.46E-11 4.83E-11 9.77E-19 1.61E-01 3.19E-16 9.26E-02
rs1801272 CYP2A6 - 1.08E-30 3.63E-34 - - - - - - - -
rs3745274 CYP2B6 3.21E-01 2.23E-01 1.95E-01 2.27E-05 2.73E-01 1.80E-01 6.90E-05 3.31E-02 2.34E-01 4.15E-04 1.30E-01
rs28399499 CYP2B6 - - - 3.33E-06 4.73E-04 - - - - 1.80E-01 -
rs1051266 SLC19A1 8.64E-03 2.37E-03 4.08E-01 3.20E-09 2.10E-01 2.71E-01 4.03E-01 3.44E-10 3.83E-02 1.97E-14 4.33E-02
rs4680 COMT 4.53E-02 8.67E-03 5.32E-01 1.75E-02 1.64E-02 2.29E-03 9.75E-01 5.38E-02 6.03E-01 3.36E-03 3.41E-01
  1. p <0.05 indicates statistical significance