Table 3 Number of variants significantly different from the 11 populations and corresponding gene families after correction for multiple tests
Gene Family | Significant Variants (N) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
TSI | MEX | GIH | CHD | CEU | CHB | ASW | JPT | MKK | LWK | YRI | |
methylenetetrahydrofolate reductase family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 2 |
cytochrome P450 superfamily | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | 2 | 2 | 4 |
UDP-glucuronosyltransferase family | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
sodium channel gene family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
nuclear receptor family | 0 | 0 | 0 | 2 | 1 | 2 | 1 | 1 | 3 | 3 | 4 |
G-protein coupled receptor family | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
alcohol dehydrogenase family | 0 | 0 | 0 | 0 | 2 | 2 | 1 | 2 | 0 | 1 | 2 |
adrenergic receptors family | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
methyltransferase superfamily | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
ATP-binding cassette (ABC) transporters superfamily | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 2 | 1 | 2 |
eag family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 |
inward-rectifier potassium channel family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
glutathione S-transferase family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Ser/Thr protein kinase family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
G-protein coupled receptor family | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 2 |
solute carrier family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
sulfotransferase family | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
- | 0 | 0 | 2 | 1 | 1 | 3 | 2 | 4 | 3 | 4 | 6 |
Sum | 0 | 1 | 3 | 5 | 7 | 9 | 10 | 12 | 16 | 17 | 25 |