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Table 4 Cox’s univariate model. Unajusted hazard ratios for PFS, MFS, OS with each of the SNPs in genotype, allelic and haplotype model

From: The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients

Reference SNP ID Genotype/allele /haplotype n Progression-free survival Metastasis-free survival Overall survival
Multivariate P value Multivariate P value Multivariate P value
Hazard ratio (CI) Hazard ratio (CI) Hazard ratio (CI)
IL10 -1082A > G Genotype model GG 37 1 0.317 1 0.456 1 0.288
GA 43 3.168 0.131 2.580 0.221 1.524 0.606
(0.709-14.157) (0.565-11.779) (0.307-7.565)
AA 20 2.840 0.182 2.493 0.248 3.138 0.168
(0.613-13.169) (0.592-11.753) (0.617-15.951)
Allelic model A allele non carriers 63 1   1   1  
A allele carriers 37 3.020 0.135 0.819 0.663 0.431 0.128
(0.708-12.885) (0.334-2.008) (0.145-1.276)
G allele non carriers 80 1   1   1  
G allele carriers 20 0.852 0.708 2.541 0.211 2.021 0.359
(0.367-1.974) (0.589-10.953) (0.450-9.086)
IL10 -819 T > C Genotype model CC 58 1 0.695 1 0.905 1 0.357
CT 33 1.456 0.396 1.234 0.665 2.029 0.242
(0.612-3.466) (0.477-3.188) (0.620-6.643)
TT 9 1.109 0.892 1.176 0.833 2.516 0.253
(0.248-4.963) (0.260-5.314) (0.518-12.221)
Allelic model C allele non carriers 91 1   1   1  
C allele carriers 9 1.042 0.956 0.918 0.909 0.502 0.370
(0.244-4.447) (0.213-3.960) (0.111-2.265)
T allele non carriers 42 1   1   1  
T allele carriers 58 1.378 0.444 1.220 0.658 2.157 0.161
(0.606-3.131) (0.505-2.950) (0.736-6.322)
IL10 -592A > C Genotype model CC 54 1 0.877 1 0.995 1 0.427
AC 36 1.131 0.637 1.048 0.923 1.849 0.311
(0.517-2.935) (0.405-2.709) (0.563-6.073)
AA 10 0.941 0.941 1.011 0.989 2.411 0.276
(0.211-4.231) (0.224-4.570) (0.495-11.728)
Allelic model C allele non carriers 90 1   1   1  
C allele carriers 10 1.152 0.848 1.007 0.992 0.512 0.384
(0.270-4.920) (0.233-4.347) (0.114-2.311)
A allele non carriers 46 1   1   1  
A allele carriers 54 1.168 0.712 1.039 0.932 1.992 0.211
(0.513-2.656) (0.430-2.515) (0.676-5.863)
TNFα -308G > A Genotype model GG 83 1 0.066 1 0.135 1 0.163
GA 14 3.049* 0.020 2.819* 0.045 3.096 0.057
(1.195-7.778) (1.021-7.780) (0.967-9.909)
AA 3 N.c. 0.981 N.c. 0.982 N.c. 0.989
Allelic model G allele non carriers 97 1   1   1  
G allele carriers 3 21.241 0.548 21.252 0.992 21.069 0.725
(0.001; >1000) (0.001; >1000) (0.001; >1000)
A allele non carriers 17 1   1   1  
A allele carriers 83 2.256 0.088 2.904 0.153 2.643 0.102
(0.887-5.738) (0.760-5.768) (0.825-8.471)
IL10 Haplotype model GCC non carriers 43 1   1   1  
GCC carriers 57 1.502 0.353 1.483 0.401 1.143 0.805
(0.637-3.544) (0.592-3.718) (0.396-3.300)
ACC non carriers 38 1   1   1  
ACC carriers 62 0.890 0,785 0.854 0.730 0.456 0.154
(0.384-2.063) (0.348-2.095) (0.155-1.343)
ATA non carriers 58 1   1   1  
ATA carriers 42 1.374 0.448 1.214 0.667 2.104 0.174
(0.605-3.121) (0.502-2.935) (0.720-6.150)
  1. *Significant associations.
  2. N.c. – no cases