Table 4 Cox’s univariate model. Unajusted hazard ratios for PFS, MFS, OS with each of the SNPs in genotype, allelic and haplotype model

IL10 -1082A > G

Genotype model

GG

37

1

0.317

1

0.456

1

0.288

GA

43

3.168

0.131

2.580

0.221

1.524

0.606

(0.709-14.157)

(0.565-11.779)

(0.307-7.565)

AA

20

2.840

0.182

2.493

0.248

3.138

0.168

(0.613-13.169)

(0.592-11.753)

(0.617-15.951)

Allelic model

A allele non carriers

63

1

1

1

A allele carriers

37

3.020

0.135

0.819

0.663

0.431

0.128

(0.708-12.885)

(0.334-2.008)

(0.145-1.276)

G allele non carriers

80

1

1

1

G allele carriers

20

0.852

0.708

2.541

0.211

2.021

0.359

(0.367-1.974)

(0.589-10.953)

(0.450-9.086)

IL10 -819 T > C

Genotype model

CC

58

1

0.695

1

0.905

1

0.357

CT

33

1.456

0.396

1.234

0.665

2.029

0.242

(0.612-3.466)

(0.477-3.188)

(0.620-6.643)

TT

9

1.109

0.892

1.176

0.833

2.516

0.253

(0.248-4.963)

(0.260-5.314)

(0.518-12.221)

Allelic model

C allele non carriers

91

1

1

1

C allele carriers

9

1.042

0.956

0.918

0.909

0.502

0.370

(0.244-4.447)

(0.213-3.960)

(0.111-2.265)

T allele non carriers

42

1

1

1

T allele carriers

58

1.378

0.444

1.220

0.658

2.157

0.161

(0.606-3.131)

(0.505-2.950)

(0.736-6.322)

IL10 -592A > C

Genotype model

CC

54

1

0.877

1

0.995

1

0.427

AC

36

1.131

0.637

1.048

0.923

1.849

0.311

(0.517-2.935)

(0.405-2.709)

(0.563-6.073)

AA

10

0.941

0.941

1.011

0.989

2.411

0.276

(0.211-4.231)

(0.224-4.570)

(0.495-11.728)

Allelic model

C allele non carriers

90

1

1

1

C allele carriers

10

1.152

0.848

1.007

0.992

0.512

0.384

(0.270-4.920)

(0.233-4.347)

(0.114-2.311)

A allele non carriers

46

1

1

1

A allele carriers

54

1.168

0.712

1.039

0.932

1.992

0.211

(0.513-2.656)

(0.430-2.515)

(0.676-5.863)

TNFα -308G > A

Genotype model

GG

83

1

0.066

1

0.135

1

0.163

GA

14

3.049*

0.020

2.819*

0.045

3.096

0.057

(1.195-7.778)

(1.021-7.780)

(0.967-9.909)

AA

3

N.c.

0.981

N.c.

0.982

N.c.

0.989

Allelic model

G allele non carriers

97

1

1

1

G allele carriers

3

21.241

0.548

21.252

0.992

21.069

0.725

(0.001; >1000)

(0.001; >1000)

(0.001; >1000)

A allele non carriers

17

1

1

1

A allele carriers

83

2.256

0.088

2.904

0.153

2.643

0.102

(0.887-5.738)

(0.760-5.768)

(0.825-8.471)

IL10

Haplotype model

GCC non carriers

43

1

1

1

GCC carriers

57

1.502

0.353

1.483

0.401

1.143

0.805

(0.637-3.544)

(0.592-3.718)

(0.396-3.300)

ACC non carriers

38

1

1

1

ACC carriers

62

0.890

0,785

0.854

0.730

0.456

0.154

(0.384-2.063)

(0.348-2.095)

(0.155-1.343)

ATA non carriers

58

1

1

1

ATA carriers

42

1.374

0.448

1.214

0.667

2.104

0.174

(0.605-3.121)

(0.502-2.935)

(0.720-6.150)