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Table 5 Cox’s multivariable model. Adjusted hazard ratios for PFS, MFS, OS with each of the known BC prognostic factor and TNFα -308G > A

From: The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients

Variable

Progression-free survival

Metastasis-free survival

Overall survival

Hazard ratio (95 % CI)

P value

Hazard ratio (95 % CI)

P value

Hazard ratio (95 % CI)

P value

TNFα -308G > A

GG genotype

1

 

1

 

1

 

GA genotype

4.631*

0.005

4.708*

0.010

4.829*

0.037

  

(1.587-13.512)

 

(1.445-15.345)

 

(1.098-21.243)

 

Age group

41-50 years

1

 

1

 

1

 

30-40 years

1.451

0.403

1.407

0.481

1.014

0.983

  

(0.606-3.477)

 

(0.544-3.639)

 

(0.283-3.634)

 

Tumor size (pathologic)

T1

1

 

1

 

1

 

T2

1.039

0.934

0.749

0.555

0.577

0.425

  

(0.419-2.581)

 

(0.286-1.960)

 

(0.149-2.233)

 

Lymph node involvement (pathologic)

N0

1

 

1

 

1

 

N1

1.876

0.192

2.349

0.199

1.346

0.628

  

(0.729-4.828)

 

(0.829-6.659)

 

(0.405-4.480)

 

Grade

G1

1

0.962

1

0.751

1

0.629

G2

1.268

0.825

1.080

0.944

0.542

0.598

 

(0.154-10.449)

 

(0.127-9.184)

 

(0.056-5.268)

 

G3

1.378

0.783

0.972

0.981

0.293

0.375

 

(0.141-13.477)

 

(0.095-9.965)

 

(0.019-4.412)

 

Intrinsic subtype

Luminal B

1

0.191

1

0.140

1

0.119

Luminal A

4.095

0.178

3.329

0.225

1.380

0.780

 

(0.526-31.892)

 

(0.419-26.433)

 

(0.144-13.257)

 

‘Basal-like’

3.872

0.233

3.248

0.317

3.966

0.285

 

(0.420-35.739)

 

(0.324-32.593)

 

(0.318-49.534)

 

HER2 overexpression

9.874*

0.044

10.177*

0.043

6.426

0.112

 

(1.068-91.312)

 

(1.080-95.880)

 

(0.646-63.903)

 
  1. *Significant associations.