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Table 5 Cox’s multivariable model. Adjusted hazard ratios for PFS, MFS, OS with each of the known BC prognostic factor and TNFα -308G > A

From: The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients

Variable Progression-free survival Metastasis-free survival Overall survival
Hazard ratio (95 % CI) P value Hazard ratio (95 % CI) P value Hazard ratio (95 % CI) P value
TNFα -308G > A GG genotype 1   1   1  
GA genotype 4.631* 0.005 4.708* 0.010 4.829* 0.037
   (1.587-13.512)   (1.445-15.345)   (1.098-21.243)  
Age group 41-50 years 1   1   1  
30-40 years 1.451 0.403 1.407 0.481 1.014 0.983
   (0.606-3.477)   (0.544-3.639)   (0.283-3.634)  
Tumor size (pathologic) T1 1   1   1  
T2 1.039 0.934 0.749 0.555 0.577 0.425
   (0.419-2.581)   (0.286-1.960)   (0.149-2.233)  
Lymph node involvement (pathologic) N0 1   1   1  
N1 1.876 0.192 2.349 0.199 1.346 0.628
   (0.729-4.828)   (0.829-6.659)   (0.405-4.480)  
Grade G1 1 0.962 1 0.751 1 0.629
G2 1.268 0.825 1.080 0.944 0.542 0.598
  (0.154-10.449)   (0.127-9.184)   (0.056-5.268)  
G3 1.378 0.783 0.972 0.981 0.293 0.375
  (0.141-13.477)   (0.095-9.965)   (0.019-4.412)  
Intrinsic subtype Luminal B 1 0.191 1 0.140 1 0.119
Luminal A 4.095 0.178 3.329 0.225 1.380 0.780
  (0.526-31.892)   (0.419-26.433)   (0.144-13.257)  
‘Basal-like’ 3.872 0.233 3.248 0.317 3.966 0.285
  (0.420-35.739)   (0.324-32.593)   (0.318-49.534)  
HER2 overexpression 9.874* 0.044 10.177* 0.043 6.426 0.112
  (1.068-91.312)   (1.080-95.880)   (0.646-63.903)  
  1. *Significant associations.