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Table 3 Association, test heterogeneity and publication bias for p53 Arg72Pro polymorphism and the risk of oral cancer

From: P53 codon 72 polymorphism, human papillomavirus infection, and their interaction to oral carcinoma susceptibility

Comparison Number of studies Sample size (case/control) Test of association Test of heterogeneity Publication bias
OR 95 %CI P value Model Q P value I2 P value (Begg’s) P value (Egger’s)
Arg72 allele vs. Pro72 allele            
Total 12 2,093/2,880 1.054 0.905-1.228 0.500 R 33.16 0.000 66.8 % 0.300 0.202
Caucasian 4 827/1,299 0.933 0.722-1.206 0.597 R 9.92 0.019 69.7 % 0.221 0.175
Asian 8 1,266/1,581 1.128 0.934-1.362 0.210 R 19.40 0.007 63.9 % 0.902 0.717
Arg/Arg vs. Pro/Pro            
Total 12 2,093/2,880 1.109 0.807-1.524 0.523 R 29.39 0.002 62.6 % 0.360 0.415
Caucasian 4 827/1,299 0.870 0.621-1.218 0.416 F 6.04 0.110 50.3 % 0.462 0.312
Asian 8 1,266/1,581 1.277 0.860-1.898 0.226 R 19.36 0.007 63.8 % 0.536 0.914
Arg/Arg + Arg/Pro vs. Pro/Pro            
Total 12 2,093/2,880 0.936 0.723-1.211 0.613 R 23.90 0.013 54.0 % 0.161 0.423
Caucasian 4 827/1,299 1.142 0.823-1.583 0.427 F 3.81 0.283 21.2 % 0.806 0.451
Asian 8 1,266/1,581 0.846 0.613-1.169 0.312 R 17.10 0.017 59.1 % 0.711 0.990
Arg/Arg vs. Arg/Pro + Pro/Pro            
Total 13 2,413/3,201 1.069 0.907-1.259 0.426 R 23.56 0.023 49.1 % 0.511 0.302
Caucasian 5 1,147/1,620 0.975 0.777-1.224 0.828 R 8.54 0.074 53.2 % 0.060 0.054
Asian 8 1,266/1,581 1.161 0.917-1.471 0.215 R 13.19 0.068 46.9 % 0.902 0.883
HPV infection 5 396/213 0.677 0.478-0.959 0.027 F 0.93 0.920 0.0 % 0.462 0.400
  1. Model Abbreviations: R = random-effect; F = fixed-effect