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Table 1 Changes in relative expression of 19 genes within tumor suppressor region located at 62.3 – 63.0 Mb (RNO10q24) distal to Tp53

From: Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region

Transcript Position (Mb) Group EC vs NME Group EC with vs EC without loss at RNO10q24
P-value <0.05 Fold change P-value <0.05
Est1a 62.23 0.002 x −2.3 0.03 x
Hic1 62.47 0.0004 x −4.9 0.2  
Ovca2 62.48 0.760     
Dph1 62.49 0.973     
Rtn4rl1 62.50 0.008 x −4.5 0.02 x
Rpa1 62.61 0.003 x −1.9 1.1  
Smyd4 62.66 0.918     
Serpinf1 62.71 0.293     
Serpinf2 62.75 0.324     
Wdr81 62.76 0.00.5 x −1.7 0.01 x
Tlcd2 62.79 0.218     
Prf8 62.81 0.054     
Rilp 62.83 0.108     
Scarf1 62.84 0.811     
Slc43a2 62.85 0.247     
Pitpn 62.91 0.0003 x −2.2 0.0004 x
Inpp5k 62.95 0.0003 x −6.8 0.2  
Myo1c 62.99 0.000003 x −4.8 0.1  
Crk 63.02 0.00001 x −3.2 0.4  
  1. Nine genes displayed significant decreased expression (nominal p-value < 0.05) in EC compared to the NME samples. Tumors were then divided into two groups of with and without deletion/AI at RNO10q24 and the gene expression data for the nine down regulated genes were reanalyzed. Down regulation of five genes (marked in bold) was not correlated with physical deletion at RNO10q24
  2. Fold changes and P-values of the different transcripts. The negative values of fold change represent a decreased expression. FC shown only for genes displaying P-values <0.05 between NME vs EC
  3. Equal variances assumed. t-test for equality of means