The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases

BMC Genomic Data

Table 1 Correlation coefficient, r, between average heterozygosity and average risk allele frequency on distance from Africa, with p-value

Disease	SNPs	Heterozygosity r with distance	p-value when compared to null distribution	Risk allele frequency r with distance	p-value when compared to null distribution
Biliary liver cirrhosis	41	-0.04	0.03*	0.63	0.3
Alopecia areata	41	-0.42	0.78	0.69	0.04*
Prostate cancer	39	-0.22	0.33	-0.46	0.31
Systemic lupus erythematosus	33	-0.37	0.75	0.60	0.42
Ulcerative colitis	32	-0.51	0.89	-0.26	0.18
Type 1 diabetes	27	-0.23	0.74	0.23	0.89
Celiac disease	26	-0.45	0.65	-0.08	0.62
Parkinson’s disease	25	-0.76	0.33	0.16	0.99
Crohn’s disease	24	-0.81	0.10	-0.29	0.31
Membranous nephropathy	20	-0.51	0.72	-0.31	0.44
Systemic sclerosis	19	-0.69	0.41	-0.74	0.05*
Primary biliary cirrhosis	15	-0.35	0.57	-0.33	0.72
Colorectal cancer	15	-0.64	0.34	-0.66	0.05
Type 2 diabetes	15	-0.83	0.03*	-0.76	0.02*
Breast cancer	14	-0.65	0.35	-0.02	0.77
Melanoma	14	-0.28	0.51	-0.42	0.22
Rheumatoid arthritis	14	-0.24	0.64	0.43	0.56
Asthma	13	-0.10	0.46	-0.20	0.56
Neuroblastoma	10	-0.04	0.52	-0.32	0.58
Polycystic ovary syndrome	10	-0.32	0.94	0.76	0.03*
Pancreatic cancer	7	-0.32	0.95	-0.71	0.06

P-value was calculated by comparing the R² values of the risk alleles to the null distributions created from 10,000 resampled SNP sets (see “Null Distributions” section in Methods). Correlation coefficient is reported instead of R² to show directionality
*These p-values are not significant when Bonferroni corrected for the ten variables for each allelic statistic or when adjusted for an FDR of 0.2

ISSN: 2730-6844