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Table 1 Correlation coefficient, r, between average heterozygosity and average risk allele frequency on distance from Africa, with p-value

From: The role of climate and out-of-Africa migration in the frequencies of risk alleles for 21 human diseases

Disease SNPs Heterozygosity r with distance p-value when compared to null distribution Risk allele frequency r with distance p-value when compared to null distribution
Biliary liver cirrhosis 41 -0.04 0.03* 0.63 0.3
Alopecia areata 41 -0.42 0.78 0.69 0.04*
Prostate cancer 39 -0.22 0.33 -0.46 0.31
Systemic lupus erythematosus 33 -0.37 0.75 0.60 0.42
Ulcerative colitis 32 -0.51 0.89 -0.26 0.18
Type 1 diabetes 27 -0.23 0.74 0.23 0.89
Celiac disease 26 -0.45 0.65 -0.08 0.62
Parkinson’s disease 25 -0.76 0.33 0.16 0.99
Crohn’s disease 24 -0.81 0.10 -0.29 0.31
Membranous nephropathy 20 -0.51 0.72 -0.31 0.44
Systemic sclerosis 19 -0.69 0.41 -0.74 0.05*
Primary biliary cirrhosis 15 -0.35 0.57 -0.33 0.72
Colorectal cancer 15 -0.64 0.34 -0.66 0.05
Type 2 diabetes 15 -0.83 0.03* -0.76 0.02*
Breast cancer 14 -0.65 0.35 -0.02 0.77
Melanoma 14 -0.28 0.51 -0.42 0.22
Rheumatoid arthritis 14 -0.24 0.64 0.43 0.56
Asthma 13 -0.10 0.46 -0.20 0.56
Neuroblastoma 10 -0.04 0.52 -0.32 0.58
Polycystic ovary syndrome 10 -0.32 0.94 0.76 0.03*
Pancreatic cancer 7 -0.32 0.95 -0.71 0.06
  1. P-value was calculated by comparing the R2 values of the risk alleles to the null distributions created from 10,000 resampled SNP sets (see “Null Distributions” section in Methods). Correlation coefficient is reported instead of R2 to show directionality
  2. *These p-values are not significant when Bonferroni corrected for the ten variables for each allelic statistic or when adjusted for an FDR of 0.2