Figure 1
From: Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?
Twelve SNPs identified in meta-GWAS for iron parameters and included in the Mendelian randomization analysis. Betas ± standard error for serum iron, transferrin, transferrin saturation (TS), and ferritin (log) based on the meta-analyses of genome-wide association studies on iron status performed by the Genetics of Iron Status Consortium (discovery and replication combined (N = 48,972)). a SNPs that are hypothesized to increase the risk of atherosclerosis according to the ‘iron hypothesis’; (b) SNPs that are hypothesized to decrease the risk of atherosclerosis according to the ‘iron hypothesis’; (c) SNPs for which the hypothesized effect on atherosclerosis risk is unknown