Table 5 Summary of evidence for and against a role of hepcidin and the iron parameters in atherosclerosis resulting from this study
From: Iron and hepcidin as risk factors in atherosclerosis: what do the genes say?
Trait | Evidence for causal role | Evidence against causal role |
|---|---|---|
Hepcidin | Weak genomic correlations with ABI at rest and ABI after exercise | - No nominally significant associations with all NIMA-related SNPs |
- Genomic correlations with presence of plaque and IMT ~0 | ||
Ferritin | - Directionally consistent associations of the multi-SNP score with NIMA in women | - No directionally consistent associations of the multi-SNP score with NIMA in men |
- Directionally consistent associations of rs651007 with NIMA | -No directionally consistent associations of other variants than rs651007 (notably rs411988) with NIMA | |
- Weak genomic correlations with ABI at rest and ABI after exercise | ||
- No nominally significant associations with all NIMA-related SNPs | ||
- Genomic correlations with presence of plaque and IMT ~0 | ||
Hepcidin/ferritin | Nominally significant associations with two NIMA-related SNPs | - No nominally significant associations with four NIMA-related SNPs |
- Genomic correlations with all NIMA ~0 | ||
Hepcidin/TS | Â | - No nominally significant associations with all NIMA-related SNPs |
- Genomic correlations with all NIMA ~0 | ||
Iron | - Directionally consistent associations of the multi-SNP score with NIMA in women | - No directionally consistent associations of the multi-SNP score with NIMA in men |
- No directionally consistent associations of iron-related SNPs with NIMA | ||
- No nominally significant associations with all NIMA-related SNPs | ||
- Genomic correlations with all NIMA ~0 | ||
TIBC | - Directionally consistent associations of the multi-SNP score with NIMA in women | - No directionally consistent associations of the multi-SNP score with NIMA in men |
- No directionally consistent associations of iron-related SNPs with NIMA | ||
- No nominally significant associations with all NIMA-related SNPs | ||
- Genomic correlations with all NIMA ~0 | ||
TS | - Directionally consistent associations of the multi-SNP score with NIMA in women | - No directionally consistent associations of the multi-SNP score with NIMA in men |
- No directionally consistent associations of iron-related SNPs with NIMA | ||
- No nominally significant associations with all NIMA-related SNPs | ||
- Genomic correlations with all NIMA ~0 |