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Table 4 Genotypic and allelic frequencies of the genetic markers in the Ladakh high altitude natives (HAN) and sea level sojourners (Accl _LLD)

From: Polymorphism profiling of nine high altitude relevant candidate gene loci in acclimatized sojourners and adapted natives

SNP

Variant

Genotype

Genotype Frequency

p

HWEa p

Allele

Allele Frequency

Fisher exact p

   

HAN

Accl_LLD

 

HAN

Accl_LLD

 

HAN

Accl_LLD

 

rs2071942

EDN1 9465G > A b

GG

0.439

0.361

0.005

0.34

0.01

G

0.681

0.534

0.01

  

GA

0.484

0.347

   

A

0.318

0.465

 
  

AA

0.075

0.291

       

rs10478694 c

EDN1 3A/4A

-3A/-3A

0.857

0.771

0.343

0.54

0.97

-3A

0.928

0.878

0.06

  

-3A/-4A

0.142

0.214

   

-4A

0.071

0.121

 
  

-4A/-4A

0

0.014

       

rs1042713

ADRB2 Arg16Gly (46A > G)

GG

0.238

0.305

0.559

0.54

0.51

G

0.507

0.569

0.3

  

AG

0.537

0.527

   

A

0.492

0.43

 
  

AA

0.223

0.166

       

rs1042714

ADRB2 Gln27Glu (79G > C)d

CC

0.612

0.338

0.005

0.57

0.04

C

0.777

0.626

0.002

  

CG

0.354

0.577

   

G

0.222

0.373

 
  

GG

0.032

0.084

       

rs4994

ADRB3 Try64Arg (5387 T > C)

TT

0.805

0.75

0.077

0.01

0.22

T

0.88

0.875

0.14

  

CT

0.149

0.25

   

C

0.119

0.125

 
  

CC

0.044

0

       

rs3025039

VEGF 963C > T

CC

0.91

0.83

0.302

0.7

0.56

C

0.955

0.908

0.06

  

CT

0.089

0.154

   

T

0.044

0.091

 
  

TT

0 (0)

0.014

       

rs1799983

eNOS Glu298Asp (894 T> G)

GG

0.723

0.666

0.582

0.69

0.71

G

0.853

0.815

0.08

  

GT

0.261

0.291

   

T

0.146

0.187

 
  

TT

0.015

0.041

       

rs6356

TH Val81Met (7085G > A)

AA

0.461

0.45

0.726

0.9

0.36

A

0.676

0.659

0.76

  

GA

0.43

0.5

   

G

0.323

0.34

 
  

GG

0.107

0.091

       
  1. aHardy-Weinberg Equilibrium; bamplification failed in three HAN samples; cthis rsID has been removed from the reference database and merged into rs1800997; damplification failed in 3 HAN and 1 sojourner sample