Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population

BMC Genomic Data

Table 3 Multivariable-adjusted hazard ratios for CHD by MEOX2 haplotypes

Haplotype Event	N° events/at risk		Hazard ratio	P	P _BH
Haplotype Event	Carrier	Non-carrier	Hazard ratio	P	P _BH
TCTTAT
All coronary events	40/951	66/1076	0.73 (0.49–1.11)	0.14	0.21
Myocardial infarction	20	33	0.77 (0.42–1.41)	0.40	0.56
Coronary revascularisation	30	48	0.75 (0.47–1.19)	0.22	0.22
Ischaemic cardiomyopathy	6	16	0.56 (0.21–1.51)	0.25	0.25
TCTTGT
All coronary events	46/937	60/1090	0.90 (0.58–1.39)	0.63	0.63
Myocardial infarction	26	27	1.19 (0.67–2.11)	0.56	0.56
Coronary revascularisation	30	48	0.74 (0.46–1.20)	0.22	0.22
Ischaemic cardiomyopathy	9	13	0.59 (0.24–1.43)	0.24	0.25
GTCCGC
All coronary events	43/614	63/1413	1.78 (1.24–2.56)	0.0018	0.0054
Myocardial infarction	23	30	1.96 (1.16–3.31)	0.012	0.036
Coronary revascularisation	33	45	1.87 (1.20–2.91)	0.0058	0.017
Ischaemic cardiomyopathy	11	11	3.16 (1.41–7.09)	0.0053	0.016

Numbers of events do not add up, because only the first event in each category was analysed. Letters coding the haplotypes refer to the rs10777, rs12056299, rs7787043, rs4532497, rs6959056 and rs1050290 alleles (see Additional file 1: Table S1 and S2). Haplotypes were reconstructed using the expectation-maximisation algorithm as implemented in the PROC HAPLOTYPE procedure of the SAS software version 9.3. Hazard ratios (95 % confidence interval) express the risk associated with carrying vs. not carrying a haplotype, account for family clusters, and were adjusted for baseline characteristics including sex, age, body mass index, systolic pressure, total-to-HDL cholesterol ratio, smoking and drinking, and antihypertensive drug treatment. P and P _BH indicate the significance of the hazard ratios without and with Benjamini-Hochberg’s correction for multiple testing

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