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Table 4 Meta-analysis results1 across ethnicities in MESA2 (p-values < 1×10−5) for each depressive symptom score modeling approach

From: Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

Approach

CHR

SNP

Location

Coded allele

Coded allele frequency

Z-score

P-value

Direction3

Closest gene4 within ±50kB

Baseline

 

8

rs2440212

97270629

A

0.66

4.47

7.73×10−6

++++

(GDF6)

 

9

rs13440434

131953827

A

0.87

−4.50

6.79×10−6

----

(GPR107)

 

10

rs7087469

54339854

A

0.13

4.76

1.93×10−6

++?+

-

 

13

rs9560521

89457392

A

0.13

4.69

2.69×10−6

++++

(LINC00559)

 

16

rs8046816

71863525

A

0.47

4.53

5.92×10−6

++++

-

 

20

rs17215529

3923402

A

0.85

4.79

1.66×10−6

++?+

RNF24

Averaged

 

1

rs3100865

2795967

T

0.49

4.44

9.02×10−6

++++

-

 

2

rs41379347

191577187

T

0.89

−4.58

4.57×10−6

??--

STAT1

 

2

rs7602149

114357038

T

0.84

−4.57

4.78×10−6

--?-

LOC728055

 

2

rs13001068

182706602

A

0.92

4.50

6.95×10−6

? + ?+

(PDE1A)

 

7

rs697521

16730681

T

0.13

−4.74

2.12×10−6

--?-

BZW2

 

8

rs7350109

60753909

A

0.81

−4.5

6.88×10−6

--?-

-

 

11

rs1448128

121291660

C

0.24

−4.58

4.61×10−6

----

-

 

22

rs5760767

23696411

T

0.51

4.58

4.62×10−6

++++

(TMEM211)

Repeated measures

 

1

rs11590206

145665933

A

0.16

−4.72

2.33×10−6

----

(GJA5)

 

2

rs41379347

191577187

T

0.89

−5.22

1.81×10−7

??--

STAT1

 

2

rs7602149

114357038

T

0.84

−4.62

3.83×10−6

--?-

LOC728055

 

4

rs13139186

96637940

T

0.90

−4.48

7.44×10−6

----

UNC5C

 

4

rs233976

104823918

A

0.21

4.47

7.75×10−6

?+++

TACR3

 

7

rs11771332

86539742

A

0.81

−4.48

7.45×10−6

?-?-

(KIAA1324L)

 

9

rs2211185

1332721

T

0.77

4.55

5.42×10−6

++++

-

 

18

rs2728505

21474070

A

0.55

−4.47

7.84×10−6

----

-

 

22

rs5760767

23696411

T

0.51

4.54

5.68×10−6

++++

(TMEM211)

  1. 1filtered at ethnicity-specific minor allele frequency 5 %, where the SNP was present in at least two ethnicities, linkage disequilibrium R2 < 80 %, and heterogeneity p-value ≥ 0.1; 2Multi-Ethnic Study of Atherosclerosis; 3Order corresponding to direction positions: African, European, Chinese, Hispanic American; 4parentheses indicate location outside of gene