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Table 5 Meta-analysis results1 between MESA2 and HRS3 (p-values < 1×10−5) for repeated measures depressive symptom score GEE analyses

From: Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis

Race

CHR

SNP

Location

Coded allele

Coded allele frequency

Z-score

P-value

Direction4,5

Closest gene6 within ±50kB

African American

 

1

rs10776776

114384683

T

0.55

4.73

2.30×10−6

++

(SYT6)

 

1

rs1417303

235193008

T

0.59

−4.43

9.46×10−6

--

LOC440737

 

2

rs4629180

101454802

A

0.83

−4.51

6.41×10−6

--

(LOC731220)

 

2

rs6711630

126534599

T

0.93

4.58

4.70×10−6

++

 
 

7

rs10249133

12514004

T

0.39

−4.47

7.67×10−6

--

(LOC100133035)

 

8

rs17067630

3661853

A

0.85

4.70

2.57×10−6

++

CSMD1

 

11

rs11036016

40661316

A

0.80

4.68

2.94×10−6

++

LRRC4C

 

15

rs4551976

49264445

T

0.63

−4.45

8.48×10−6

--

(CYP19A1)

 

16

rs365962

85267450

C

0.69

−4.53

5.83×10−6

--

(LOC101928614)

 

20

rs2426733

55454729

A

0.40

−4.75

2.07×10−6

--

(RBM38)

European American

 

1

rs12031875

71357685

A

0.82

4.81

1.54×10−6

++

ZRANB2-AS2

 

4

rs6842756

185341452

A

0.92

4.98

6.54×10−7

++

ENPP6

 

6

rs6941340

16145531

T

0.48

−4.47

7.95×10−6

--

 
 

9

rs11794102

111772109

A

0.91

4.54

5.70×10−6

++

PALM2-AKAP2

 

13

rs6492314

110267411

C

0.28

−4.75

2.00×10−6

--

 
 

16

rs12921740

20219533

T

0.51

−4.55

5.44×10−6

--

(GP2)

 

18

rs2612547

41290709

A

0.83

4.47

7.94×10−6

++

SLC14A2

All samples

 

1

rs2300177

71270950

T

0.19

−4.56

5.09×10−6

? − +−−?

PTGER3

 

1

rs1539418

145676734

A

0.16

−4.53

5.87×10−6

----??

 
 

1

rs7415169

168997688

A

0.85

4.70

2.58×10−6

++++++

 
 

2

rs6711630

126534599

T

0.93

4.58

4.70×10−6

+????+

 
 

2

rs41379347

191577187

T

0.89

−5.22

1.81×10−7

??--??

STAT1

 

4

rs6552764

185341497

A

0.86

4.64

3.41×10−6

− + ? − ++

ENPP6

 

8

rs12541177

124869454

T

0.31

−4.48

7.43×10−6

------

FAM91A1

 

9

rs9408311

38704682

T

0.84

4.92

8.87×10−7

++ − +++

 
 

15

rs16975781

94245464

T

0.90

4.62

3.83×10−6

+++++−

 
 

16

rs12921740

20219533

T

0.59

−4.70

2.61×10−6

-−− + −−

(GP2)

  1. 1Filtered at ethnicity-specific minor allele frequency of 5 %, where the SNP was present in at least two ethnicities, linkage disequilibrium R2 < 80 %, and heterogeneity p-value ≥ 0.1; 2Multi-Ethnic Study of Atherosclerosis; 3Health and Retirement Study 4Order corresponding to direction positions: African, European, Chinese, Hispanic American; 5For all samples analyses, order corresponding to direction position: MESA African American, MESA European American, MESA Chinese American, MESA Hispanic American, HRS European American, HRS African American; 6parentheses indicate location outside of gene