MC1R diversity in Northern Island Melanesia has not been constrained by strong purifying selection and cannot explain pigmentation phenotype variation in the region

Table 2 Summary statistics for MC1R in Melanesian sample and for 1000 Genomes populations (AFR = LWK, YRI; EUR = CEU, FIN, GBR, IBS, TSI; EAS = CHB, CHD, JPT; SAS = BEB, GIH, ITU, PJL, STU)

Population	2 N	bp	S	# of haplotypes	π	θ	Tajima’s D	FWH
Melanesia	376	954	5	8	0.00075	0.00081	−0.117	−0.543
Bougainville	72	954	2	3	0.00056	0.00043	0.486	−0.761
New Hanover	122	954	5	7	0.00099	0.00097	0.036	−0.191
New Britain	64	954	3	5	0.00067	0.00067	0.012	−0.850
New Ireland	112	954	4	6	0.00065	0.00079	−0.361	−0.715
Austronesian speaking	246	954	4	7	0.00087	0.00069	0.445	−0.362
Non-Austronesian speaking	124	954	3	5	0.00050	0.00058	−0.249	−0.934
AFR	370	954	10	13	0.00086	0.00162	−1.019	0.160
LWK	194	954	9	10	0.00082	0.00161	−1.12	0.123
YRI	176	954	7	9	0.00090	0.00128	−0.631	0.193
EUR	758	954	17	18	0.00104	0.00247	−1.338	−2.749
CEU	170	954	9	10	0.00101	0.00165	−0.902	−2.866
FIN	186	954	11	11	0.00107	0.00199	−1.109	−0.863
GBR	178	954	10	11	0.00122	0.00182	−0.778	−0.437
IBS	28	954	4	5	0.00054	0.00108	−1.30	−1.481
TSI	196	954	14	15	0.00087	0.00251	−1.65	−0.898
EAS	572	954	8	10	0.00138	0.00121	0.269	−0.802
CHB	194	954	6	6	0.00142	0.00108	0.657	−0.787
CHD	200	954	5	5	0.00157	0.00089	1.451	−0.285
JPT	178	954	6	8	0.00098	0.00109	−0.220	−1.697
SAS	978	954	23	24	0.00061	0.00323	−1.939	−2.662
BEB	172	954	7	8	0.00070	0.00128	−0.989	−0.611
GIH	206	954	13	14	0.00059	0.00231	−1.833	−0.635
ITU	204	954	12	13	0.00064	0.00213	−1.700	−2.672
PJL	192	954	10	11	0.00060	0.00180	−1.562	−0.677
STU	204	954	9	10	0.00056	0.00160	−1.479	−0.741

ISSN: 2730-6844