Fig. 1
From: Leveraging local ancestry to detect gene-gene interactions in genome-wide data
Simulation schemes. Main and interaction effects are simulated assuming either a single genetic variant per locus (a) or multiple genetic variants per locus (b). In the latter case, the main and interaction effects on the outcome Y are moderated through two latent variables Z1 and Z2 that directly depend on the causal variants. Example of local ancestry derived for the two haplotypes of three individuals (c)