Interaction of smoking and obesity susceptibility loci on adolescent BMI: The National Longitudinal Study of Adolescent to Adult Health

Table 2 Stratified analysis of nominally significant (p < 0.05) SNP-by-smoking interactions on %MBI in Add Health

	European American (EA) Nonsmokers		European American (EA) Smokers
POC5 (rs2112347)	Beta [95 % CI]	p	Beta [95 % CI]	p
All	0.04 [−1.19, 1.27]	0.947	1.75 [0.22, 3.28]	0.025
Females	1.22 [−0.49, 2.93]	0.16	2.76 [0.55, 4.97]	0.014
Males	−1.48 [−3.26, 0.30]	0.102	1.03 [−1.01, 3.07]	0.324
MC4R (rs571312)	Beta [95 % CI]	p	Beta [95 % CI]	p
All	1.46 [0.09, 2.83]	0.036	3.50 [1.78, 5.22]	7.54E–05
Females	1.11 [−0.79, 3.01]	0.253	5.48 [3.07, 7.89]	8.37E–06
Males	2.05 [0.07, 4.03]	0.042	0.87 [−1.58, 3.32]	0.489
	Hispanic American (HA) Nonsmokers		Hispanic American (HA) Smokers
TNNI3K (rs1514175)	Beta [95 % CI]	p	Beta [95 % CI]	p
All	−1.80 [−4.09, 0.49]	0.123	5.97 [2.36, 9.58]	0.001
Females	−2.00 [−5.21, 1.21]	0.223	6.41 [0.92, 11.90]	0.022
Males	−1.78 [−4.99, 1.43]	0.279	5.25 [0.39, 10.11]	0.033

Bold highlights nominally significant associations (p ≤ 0.05). Mixed effects model, BMI = β + βSNPxSMK + βSNP + βSMK + βage + βsex + f + s + ε, Betas shown in table refer to βSNPxSMK. %MBMI = Percent of the CDC/NCHS 2000 median BMI

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