Table 3 Metabolic pathways associated with asthma symptoms suggested by enrichment analysis
From: A genome-wide association study of asthma symptoms in Latin American children
Metabolic pathway | Total number of genes in the interval | N° of associated genes in the interval | Genes | p-empirical | p-corrected |
|---|---|---|---|---|---|
GO:0030097: haematopoiesis | 52 | 7 | CD164 (chr6), KIRREL3 (chr11), BRCA2 (chr13), RPA1 (chr17), BCL11A (chr2), PKNOX1 (chr21), IKZF1 (chr7). | 7.90 × 10−04 | 0.76 |
GO:0070935: 3′-UTR-mediated mRNA stabilization | 3 | 2 | TARDBP (chr1), ELAVL1 (chr19). | 1.39 × 10−03 | 0.94 |
GO:001961: flagellum | 1 | 4 | CATSPERB (chr11), SPAG16 (chr2), SPAG17 (chr1), CATSPER1 (chr14). | 1.39 × 10−03 | 0.94 |
GO:0043922: negative regulation by host of viral transcription | 4 | 2 | POU2F3 (chr11),TARDBP (chr1). | 1.79 × 10−03 | 0.94 |
GO:000369: DNA clamp loader activity | 5 | 2 | RFC2 (chr7), RFC5 (chr12). | 4.19 × 10−03 | 0.99 |
GO:0030212: hyaluronan metabolic process | 6 | 2 | ITIH5 (chr10), ITIH2 (chr10). | 4.19 × 10−03 | 0.99 |
GO:0050291: sphingosine N-acyltransferase activity | 5 | 2 | LASS4 (chr19), LASS3 (chr15). | 4.59 × 10−03 | 0.99 |
GO:0005663: DNA replication factor C complex | 6 | 2 | RFC2 (chr7), RFC5 (chr12). | 5.19 × 10−03 | 0.99 |
GO:004649: S-adenosylhomocysteine metabolic process | 6 | 2 | TPMT (chr6), DNMT3A (chr2). | 5.19 × 10−03 | 0.99 |
GO:0006297: nucleotide-excision repair, DNA gap filling | 17 | 3 | RPA1 (chr17), RFC5 (chr12), RFC2 (chr7). | 5.79 × 10−03 | 1 |