A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

Table 2 Genome-wide significant results for FEV₁/FVC in the meta-analysis. The SNP with the lowest p value within each region or gene is listed ordered by chromosome number

SNP	Position (bp)	CHR	Nearest Gene	Coded Allele	COPDGene NHW			COPDGene AA			Meta-Analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS
SNP	Position (bp)	CHR	Nearest Gene	Coded Allele	Allele Freq	Beta	P	Allele Freq	Beta	P	Allele Freq	Beta	P
rs72738834	218623888	1	TGFB2	G/G/A	0.79	−0.01	0.00276	0.834	−0.017	5.34E-05	0.81	−0.013	6.51E-09
rs6837671	89873092	4	FAM13A	G/G/A	0.60	−0.01	5.18E-06	0.416	0.007	0.03196	0.535	0.013	5.45E-13
rs13141641	145506456	4	LOC646576 (near HHIP)	C/C/T	0.60	−0.02	5.72E-09	0.888	−0.015	0.00477	0.632	−0.018	9.52E-20
rs72981684	102724211	11	MMP12	T/T/T	0.88	−0.02	2.46E-07	0.968	−0.024	0.02783	0.114	0.019	3.92E-10
rs72981675	102721251	11	MMP3	T/T/T	0.88	−0.02	2.80E-07	0.968	−0.024	0.02842	0.114	0.019	3.65E-10
rs754388	93115410	14	RIN3	G/G/C	0.82	−0.02	3.17E-07	0.85	−0.01	0.00898	0.83	−0.014	5.54E-09
rs56077333	78899003	15	CHRNA3	A/A/A	0.65	−0.02	4.70E-10	0.816	0.019	6.02E-06	0.314	−0.018	9.55E-20
rs8042849	78817929	15	AGPHD1	C/C/T	0.56	0.02	2.71E-10	0.568	0.008	0.02729	0.561	0.015	2.81E-15
rs17486278	78867482	15	CHRNA5	C/C/A	0.63	0.02	2.28E-09	0.709	0.016	3.14E-06	0.65	0.017	4.48E-20
rs58365910	78849034	15	PSMA4	C/C/T	0.628	0.016	2.28E-09	0.747	0.011	0.00475	0.655	0.015	1.24E-15
rs17487223	78923987	15	CHRNB4	G/T/T	0.616	0.016	9.73E-09	0.882	0.013	0.00999	0.349	−0.016	3.28E-15
rs17484524	78772676	15	IREB2	G/G/A	0.639	0.015	1.86E-07	0.936	0.01	0.138	0.666	0.015	4.83E-13
rs12913260	79071095	15	ADAMTS7	A/A/A	0.59	0.02	1.60E-05	0.88	0.004	0.53	0.371	−0.015	4.82E-08
rs56113850	41353107	19	CYP2A6	T/C/T	0.60	−0.02	2.46E-05	0.562	0.01	0.01955	0.462	0.014	5.19E-09

The “Coded Allele” column refers to the reference allele where the first reference allele is for the COPDGene NHW cohort, the second reference allele is for the COPDGene AA cohort, and the third reference allele is for the meta-analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS. Note that FEV₁/FVC was measured on the proportion scale (0–1) and not the percentage scale (0–100)

ISSN: 2730-6844