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Table 3 Genome-wide significant results for FEV1 in the meta-analysis. The SNP with the lowest p value within each region or gene is listed ordered by chromosome number

From: A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry

SNP

Position (bp)

CHR

Gene/Nearest Gene

Coded Allele

COPDGene NHW

COPDGene AA

Meta-Analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS

Allele Freq

Beta

P

Allele Freq

Beta

P

Allele Freq

Beta

P

rs10863398

218588279

1

TGFB2

A/A/A

0.883

−0.055

0.00539

0.695

−0.07

4.94E-05

0.202

0.067

1.06E-08

rs138641402

145445779

4

LOC646576 (near HHIP)

T/T/A

0.641

−0.067

2.28E-06

0.919

−0.09

0.00479

0.668

−0.083

8.99E-15

rs6837671

89873092

4

FAM13A

G/G/A

0.595

0.057

1.11E-05

0.416

0.059

0.00024

0.537

0.064

2.89E-13

rs1108581

136505241

9

DBH

A/A/A

0.196

0.068

2.29E-05

0.438

0.045

0.00394

0.292

−0.058

8.72E-09

rs56077333

78899003

15

CHRNA3

A/A/A

0.649

0.089

9.49E-11

0.816

0.079

0.00014

0.318

−0.084

5.29E-18

rs8031948

78816057

15

AGPHD1

T/T/T

0.63

0.084

2.61E-10

0.838

0.05

0.02287

0.336

−0.075

2.86E-15

rs17486278

78867482

15

CHRNA5

C/C/A

0.632

0.085

1.44E-10

0.709

0.073

4.31E-05

0.647

0.079

3.48E-18

rs17487223

78923987

15

CHRNB4

T/T/T

0.616

0.081

1.82E-09

0.882

0.066

0.01205

0.353

−0.076

2.06E-14

rs2568494

78740964

15

IREB2

G/G/A

0.367

−0.076

7.25E-09

0.443

−0.028

0.07723

0.545

−0.062

1.66E-12

rs58365910

78849034

15

PSMA4

C/C/T

0.628

0.085

1.65E-10

0.747

0.045

0.01584

0.652

0.072

6.69E-15

rs56113850

41353107

19

CYP2A6

T/C/T

0.596

−0.067

0.00045

0.562

0.048

0.01985

0.458

0.067

1.51E-08

  1. The “Coded Allele” column refers to the reference allele where the first reference allele is for the COPDGene NHW cohort, the second reference allele is for the COPDGene AA cohort, and the third reference allele is for the meta-analysis of COPDGene NHW, COPDGene AA, ECLIPSE and GenKOLS