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Table 1 Genes differentially expressed in ISIAH and WAG hypothalami and referred to in Databases as associated with hypertension and blood pressure regulation

From: Genome-wide transcriptome analysis of hypothalamus in rats with inherited stress-induced arterial hypertension

Gene symbol

Acc.#

Gene name

log2 fold_change ISIAH/WAG

Rat Genome Database

Chi3l1 a,b

NM_053560

chitinase 3-like 1 (cartilage glycoprotein-39)

−1.27

Cst3 a,c,b

NM_012837

cystatin C

−0.59

Cyp11b1

NM_012537

cytochrome P450, family 11, subfamily b, polypeptide 1

1.06

Cyp11b2 a,c,b

NM_012538

cytochrome P450, family 11, subfamily b, polypeptide 2

1.06

Ephx2 a,c,b

NM_022936

epoxide hydrolase 2, cytoplasmic

4.40

Fn1 a

NM_019143

no definition)

−0.98

Gstm2

NM_177426

glutathione S-transferase mu 2

−0.74

Hyal1

NM_207616

hyaluronoglucosaminidase 1

0.71

Igfbp2 a,c

NM_013122

insulin-like growth factor binding protein 2

−0.92

Ltbp2

NM_021586

latent transforming growth factor beta binding protein 2

−2.88

Prkcd a,c,b

NM_133307

protein kinase C, delta

0.63

Ptgds a,c,b

NM_013015

prostaglandin D2 synthase (brain)

−0.57

RT1-Ba a,b

NM_001008831

RT1 class II, locus Ba

−0.80

RT1-Bb a,b

NM_001004084

RT1 class II, locus Bb

−1.26

RT1-Db1 a,b

NM_001008884

RT1 class II, locus Db1

−0.76

Slc6a3 a

NM_012694

solute carrier family 6 (neurotransmitter transporter), member 3

−1.34

DAVID

P2rx4

NM_031594

purinergic receptor P2X, ligand-gated ion channel 4

−0.86

Sult1a1

NM_031834

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

−0.63

  1. Genes associated with: a- central nervous system diseases; b- cerebrovascular disorders; c- insulin resistance; ISIAH and WAG – rat strains used in the study. DAVID - Database for Annotation, Visualization and Integrated Discovery