Family-based approaches: design, imputation, analysis, and beyond

BMC Genomic Data

Table 1 Data and trait analysis methods used

First author [ref]	Chr	Trait source	Traits	SNP set^a	Pedigrees^b	Trait analysis programs^b
First author [ref]	Chr	Trait source	Traits	SNP set^a	Pedigrees^b	Transmission	Correlation
Bhatnagar [30]	All	Sim	None, HTN	No	Reduced, complete	TDT, PDT, FBAT	NA
Darst [41]	3,11	Sim	SBP	Yes	Reduced, complete	FBAT	MONSTER
Lent [33]	3	None	None	No	Reduced	NA	NA
Lin [39]	All	Real	HTN	Yes	Reduced	CAPL	NA
Papachristou [34]	All	Sim	SBP	No	Complete	NA	GEMMA, LMM + Lasso
Saad [32]	3	Sim	None, DBP	No	Complete, augmented	MORGAN, IBDstitch	NA
Sippy [31]	3	Sim	SBP	Yes	Reduced	NA	FARVAT
Wang [38]	All	Sim	DBP, SBP, HTN	Yes	Reduced	FBAT	NA
Zhou [35]	1,3, 11	Real, sim	DBP, SBP	No	Complete	NA	MENDEL

All all odd-numbered chromosomes, CAPL combined association in the presence of linkage, Chr chromosome, DBP diastolic blood pressure, FARVAT family-based rare variant association test, FBAT family-based association test, GEMMA genome-wide efficient mixed-model analysis, HTN hypertension, Lasso least absolute shrinkage and selection operator, LMM linear mixed model, Mendel MONSTER minimum p value optimized nuisance parameter score test extended to relatives, NA not applicable, PDT pedigree disequilibrium test, SBP systolic blood pressure, sim simulated, SNP single nucleotide polymorphism, TDT transmission disequilibrium test
^aWhether or not a SNP-set approach was used
^bSee text

ISSN: 2730-6844