Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Davis, Sharon K.; Xu, Ruihua; Gebreab, Samson Y.; Riestra, Pia; Gaye, Amadou; Khan, Rumana J.; Wilson, James G.; Bidulescu, Aurelian

doi:10.1186/s12863-015-0319-4

Table 4 Association between plasma adiponectin level and ADIPOQ SNPs among men and women in the Jackson Heart Study, N = 2,968*

From: Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study

Men, n = 1,131
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	−0.10(0.05)	0.0578	−0.09(0.05)	0.0652	−0.14(0.06)	0.0124	−0.09(0.05)	0.1075	−0.10(0.06)	0.0603	−0.10(0.06)	0.0914
rs12495941	G/T	−0.12(0.14)	0.3822	−0.08(0.14)	0.5438	−0.12(0.16)	0.4513	0.04(0.17)	0.8283	−0.01(0.18)	0.9377	−0.03(0.18)	0.8546
rs7627128	C/A	−0.19(0.20)	0.3345	−0.12(0.19)	0.5436	−0.13(0.26)	0.6145	−0.25(0.24)	0.2962	−0.30(0.24)	0.2086	−0.31(0.24)	0.1968
rs9877202	A/G	−0.08(0.06)	0.1709	−0.08(0.06)	0.1652	−0.10(0.06)	0.1192	−0.06(0.06)	0.3117	−0.09(0.06)	0.1764	−0.10(0.07)	0.1207
rs2036373	T/G	−1.12(0.52)	0.0335	−1.16(0.51)	0.0240	−0.92(0.57)	0.1080	−0.14(0.56)	0.7934	−0.47(0.60)	0.4295	−0.52(0.59)	0.3827
rs1501299	G/T	−0.01(0.06)	0.9324	−0.01(0.06)	0.8870	−0.06(0.07)	0.410	−0.12(0.06)	0.0719	−0.13(0.07)	0.0533	−0.14(0.07)	0.0491
rs3821799	T/C	0.04(0.04)	0.3710	0.03(0.04)	0.4916	0.02(0.04)	0.6712	0.007(0.04)	0.8744	−0.01(0.04)	0.9014	−0.01(0.04)	0.8580
rs9842733	A/T	−0.17(0.20)	0.3862	−0.19(0.19)	0.3223	−0.33(0.22)	0.1436	−0.20(0.20)	0.3165	−0.32(0.24)	0.1378	−0.33(0.21)	0.1284
Women, n = 1,837
SNPs	Alleles	Model 1^┼		Model 2^╪		Model 3^§		Model 4^║		Model 5^¶		Model 6^#
		β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value	β (SE)	P-value
rs16861205	G/A	−0.14(0.04)	0.0001	−0.14(0.04)	0.0002	−0.11(0.04)	0.0089	−0.10(0.04)	0.017	−0.13(0.05)	0.006	−0.13(0.05)	0.003
rs12495941	G/T	0.09(0.08)	0.3047	0.12(0.08)	0.1551	0.008(0.12)	0.9416	0.06(0.10)	0.5292	0.07(0.11)	0.5227	0.07(0.11)	0.5428
rs7627128	C/A	−0.06(0.15)	0.6956	−0.01(0.15)	0.9514	−0.15(0.20)	0.4585	−0.32(0.19)	0.0874	−0.58(0.23)	0.0117	−0.61(0.23)	0.0084
rs9877202	A/G	−0.05(0.04)	0.2295	−0.05(0.04)	0.1939	−0.05(0.05)	0.3580	−0.03(0.05)	0.5442	−0.07(0.05)	0.1939	−0.07(0.06)	0.1789
rs2036373	T/G	0.21(0.37)	0.5682	0.10(0.36)	0.7810	0.23(0.37)	0.5343	0.25(0.33)	0.4459	0.43(0.39)	0.2669	0.42(0.39)	0.2745
rs1501299	G/T	−0.14(0.05)	0.004	−0.15(0.05)	0.001	−0.13(0.06)	0.0258	−0.03(0.05)	0.510	−0.12(0.06)	0.0472	−0.12(0.06)	0.0468
rs3821799	T/C	0.03(0.03)	0.2802	0.03(0.03)	0.2768	0.02(0.03)	0.4649	0.02(0.03)	0.5966	0.02(0.04)	0.5226	0.03(0.04)	0.4464
rs9842733	A/T	−0.15(0.12)	0.2107	−0.10(0.12)	0.3741	0.05(0.14)	0.6928	0.02(0.14)	0.9038	−0.01(0.16)	0.9561	0.005(0.16)	0.9748

^*N represents 52 missing values for adiponectin
^┼Model 1: crude
^╪Model 2: adjusted for age
^§Model 3: adjusted for age, PEA
^║Model 4: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, blood glucose, HOMA-IR
^¶Model 5: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, blood glucose, HOMA-IR, smoking status, physical activity score, BMI, alcohol consumption status
^#Model 6: adjusted for age, PEA, LDL, HDL, triglyceride, CRP, plasma leptin, blood glucose, HOMA-IR, smoking status, physical activity score, BMI, alcohol consumption status, socioeconomic status (education level)
Two-tailed level of significance established as P ≤ 0.006

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