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Table 1 Aortic Pulse Wave Velocity and aortic strain in Dahl S, Dahl R and F2 intercross populations at six weeks of age

From: Sex-specific genetic determinants for arterial stiffness in Dahl salt-sensitive hypertensive rats

Cohort

n

PWVaorta

STRaorta

Males

Dahl R

6

2.56 ± 0.42

0.179 ± 0.012

Dahl S

4

7.96 ± 1.88

0.142 ± 0.008

F2 intercross

142

4.72 ± 2.09

0.176 ± 0.002

Females

Dahl R

6

2.51 ± 0.92

0.185 ± 0.009

Dahl S

6

6.42 ± 0.54

0.104 ± 0.022

F2 intercross

140

4.77 ± 1.95

0.177 ± 0.002

Statistical testing

Dahl S vs Dahl R, M

 

P < 0.001

P = 0.030

Dahl S vs F2, M

 

P = 0.004

P = 0.008

Dahl R vs F2, M

 

P = 0.013

P = n.s.

Dahl S vs Dahl R, F

 

P = 0.001

P < 0.001

Dahl S vs F2, F

 

P = 0.040

P < 0.001

Dahl R vs F2, F

 

P = 0.009

P = n.s.

  1. Data is presented for populations and traits informative for QTL detection (male, female F2 populations phenotyped for PWV and STR). Values are Mean ± standard deviation; PWV pulse wave velocity, STR aortic proximal strain, M male, F female; Animals were maintained on Purina (0.4 % NaCl) rat diet from inception; P, Two Way ANOVA followed by Holm-Sidak test for multiple comparisons