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Table 2 The non-synonymous single amino acid variation in MYH1 from Jeju Native Pig and Berkshire

From: An integrated in silico approach for functional and structural impact of non- synonymous SNPs in the MYH1 gene in Jeju Native Pigs

Chr. position

CDS

Position and substitutions of amino acid

SIFT

PROVEAN

(cutoff = −2.5)

PolyPhen2

I-Mutant 3.0

(DDGaKcal/mole)

PANTHERb

       

subPSEC

Pdeleterious

JNP

        

12.57978043

17

M881R

0.00

−3.116

0.544

−0.62

−2.39

0.35

12.57978052

17

L884T

0.00

−3.652

0.964

−1.92

−4.25

0.77

12.57978091

17

A897T

0.03

−2.363

0.001

−0.66

−2.03

0.27

12.57979374

18

K970A

0.00

−5.027

0.913

−0.25

−2.04

0.27

12.57979379

18

K972C

0.00

−6.630

1.000

−0.31

−5.38

0.91

12.57979382

18

H973G

0.00

−7.257

0.443

−0.44

−2.55

0.38

12.57979388

18

T975V

0.00

−3.986

0.023

−0.29

−2.64

0.41

12.57979406

18

N981G

0.00

−4.794

0.053

−0.61

−3.08

0.52

12.57981606

23

Q1285C

0.00

−4.127

0.889

−0.82

−3.88

0.70

12.57981608

23

T1286P

0.01

−3.669

0.976

−0.36

−2.92

0.48

Berkshire

        

12.57978091

17

A897T

0.03

−2.207

0.724

−0.66

−2.03

0.27

12.57979342

18

H973G

0.00

−7.257

1.000

−0.44

−2.55

0.38

12.57981608

23

T1286P

0.01

−3.669

0.976

−0.36

−2.92

0.48

  1. aDDG < −0.5: Large Decrease of Stability; DDG > 0.5: Large Increase of Stability
  2. bA cutoff of −3 corresponds to a 50 % probability that a score is deleterious