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Table 2 The non-synonymous single amino acid variation in MYH1 from Jeju Native Pig and Berkshire

From: An integrated in silico approach for functional and structural impact of non- synonymous SNPs in the MYH1 gene in Jeju Native Pigs

Chr. position CDS Position and substitutions of amino acid SIFT PROVEAN
(cutoff = −2.5)
PolyPhen2 I-Mutant 3.0
(DDGaKcal/mole)
PANTHERb
        subPSEC Pdeleterious
JNP         
12.57978043 17 M881R 0.00 −3.116 0.544 −0.62 −2.39 0.35
12.57978052 17 L884T 0.00 −3.652 0.964 −1.92 −4.25 0.77
12.57978091 17 A897T 0.03 −2.363 0.001 −0.66 −2.03 0.27
12.57979374 18 K970A 0.00 −5.027 0.913 −0.25 −2.04 0.27
12.57979379 18 K972C 0.00 −6.630 1.000 −0.31 −5.38 0.91
12.57979382 18 H973G 0.00 −7.257 0.443 −0.44 −2.55 0.38
12.57979388 18 T975V 0.00 −3.986 0.023 −0.29 −2.64 0.41
12.57979406 18 N981G 0.00 −4.794 0.053 −0.61 −3.08 0.52
12.57981606 23 Q1285C 0.00 −4.127 0.889 −0.82 −3.88 0.70
12.57981608 23 T1286P 0.01 −3.669 0.976 −0.36 −2.92 0.48
Berkshire         
12.57978091 17 A897T 0.03 −2.207 0.724 −0.66 −2.03 0.27
12.57979342 18 H973G 0.00 −7.257 1.000 −0.44 −2.55 0.38
12.57981608 23 T1286P 0.01 −3.669 0.976 −0.36 −2.92 0.48
  1. aDDG < −0.5: Large Decrease of Stability; DDG > 0.5: Large Increase of Stability
  2. bA cutoff of −3 corresponds to a 50 % probability that a score is deleterious