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Table 3 Molecules with at least 15 connections (i.e., hubs) in the network depicted in Fig. 2 (i.e., red and yellow nodes), ranked by the number of connections for each molecule. The molecules in boldface are focus genes

From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients

Cancer paina

IPA symbol

# of connections

TNF

64

IFNG

49

IL1B

44

CXCL8

42

IL6

39

Lh

39

FSH

38

NFkB (complex)

38

IL10

31

P38 MAPK

28

ERK1/2

24

PTGS2

24

IL4

23

IL1RN

22

CD3

21

Vegf

20

IL13

19

PI3K (complex)

19

IL12 (complex)

17

NFKB1

17

TCR

17

Akt

16

Fcer1

16

Cg

15

Interferon alpha

15

  1. aIn the network depicted in Fig. 2, 25 out of 140 molecules have at least 15 connections