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Table 5 Top 20 diseases and functions discovered by IPA core analyses of focus genes reported to be associated with cancer pain in the literaturea

From: MAPK1/ERK2 as novel target genes for pain in head and neck cancer patients

Categories

Function annotation

p Value

Lipid metabolism, small molecule biochemistry

Synthesis of prostaglandin

1.50E-24

Inflammatory disease

Chronic inflammatory disorder

3.74E-24

Drug metabolism, lipid metabolism, small molecule biochemistry

Synthesis of prostaglandin E2

4.34E-24

Lipid metabolism, molecular transport, small molecule biochemistry

Concentration of eicosanoid

2.19E-21

Gastrointestinal disease, inflammatory disease

Inflammatory bowel disease

1.03E-20

Lipid metabolism, molecular transport, small molecule biochemistry

Concentration of lipid

4.13E-20

Lipid metabolism, small molecule biochemistry

Fatty acid metabolism

6.51E-20

Lipid metabolism, small molecule biochemistry

Synthesis of lipid

1.01E-19

Gastrointestinal disease, inflammatory disease, inflammatory response

Ulcerative colitis

1.74E-19

Connective tissue disorders, immunological disease, inflammatory disease, skeletal and muscular disorders

Rheumatoid arthritis

1.84E-19

Connective tissue, inflammatory disease, skeletal and muscular disorders

Rheumatic disease

4.11E-19

Connective tissue disorders, inflammatory disease, skeletal and muscular disorders

Arthritis

7.15E-19

Inflammatory response

Inflammation of organ

1.19E-18

Immunological disease

Systemic autoimmune syndrome

1.57E-18

Infectious disease

Sepsis

3.20E-18

Inflammatory response

Inflammation of body region

4.40E-17

Lipid metabolism, molecular transport, small molecule biochemistry

Concentration of prostaglandin

4.51E-16

Infectious disease

Dengue hemorrhagic fever

6.48E-16

Inflammatory disease, organismal injury and abnormalities, respiratory disease

Acute respiratory distress syndrome

1.53E-15

Cell-to-cell signaling and interaction, hematological system development and function, immune cell trafficking, inflammatory response

Activation of dendritic cells

2.59E-15

  1. aRanked by p values