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Fig. 1 | BMC Genetics

Fig. 1

From: Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico

Fig. 1

Dynamics of selective sweeps, recombination rate and linkage disequilibrium (LD) in the chr10:113925369–115925369 region (a) and (b), The y axis on the left side is the negative logarithm of the p-value of association of case-controls of the Sigma Project samples. The y axis on right side is the recombination rate (cM/Mb) calculated by the 1000 Genomes Project. The recombination peaks are represented by the solid blue line. r2 was 0–1 and was calculated for the African population only. The color spectrum of the spheres is a function of the r2 value. (c) The first segment is the genomic coordinates of chromosome 10 based on mutations identified in the Indigenous population and the selective sweep peaks determined only from the Sigma Project samples. The dashed black circles indicate overlap of the recombination hotspots with the selective sweep peaks. The second segment represent the location in chromosome 10 of the hits of the Sigma Project mutations against the GWAS databases. The third segment includes mutations associated with T2D. Red indicates associated mutations, and blue indicates mutations inside the limit cutoff of the Manhattan plot. The fourth segment is the genomic context of the analyzed region, with the exons and introns of each gene. The x axis shows the coordinates of chromosome 10

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