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Fig. 2 | BMC Genetics

Fig. 2

From: Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico

Fig. 2

Distribution and patterns of SNPs in the TCF7L2 gene. At the top is the x axis, which comprises the coordinates of chromosome 10. a) Distribution of SNPs identified in the Indigenous population along the TCF7L2 gene; mutations identified in the Sigma Project and UCSC gene description, i.e., the number of exons and introns. b) Human mRNAs, the location of mRNA along the TCF7L2 gene; Splice ETs, chromosomal position of Human ETs with splice; Human ETs, distribution of human Ets; Poly(A) sites, dispersion of sites associated along a tissue-specific region; UniGene, alignments of all mRNA and EST tracks from TCF7L2 transcription; TFBS (Transcription Factor Binding Sites) conserved, in the figure, each box represents one site conserved in the human/mouse/rat alignment; TargetScan miRNA Regulatory Sites, this track shows conserved mammalian microRNA regulatory target sites in the 3’ UTR regions of TCF7L2. c) Genomic location of variants used in the identification of selective sweeps in the Neanderthal genome. Dashed red circles indicate mutations that are under selective sweeps. d) Genetic differentiation and patterns of variation in the TCF7L2 gene identified in the 1000 Genomes Project for all populations

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