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Table 2 Model estimates of interaction between 20p13 and 2q14

From: Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma

 

Most significant interaction in the follow-up analysis

Most significant interaction in the surrounding region

20p13: rs910652 (T/C) main effect

2q14: rs11684871 (G/A) main effect

rs910652 × rs11684871 interaction

20p13: rs1018491 (T/C) main effect

2q14: rs67959717 (G/A) main effect

rs1018491× rs67959717 interaction

OR (95 % CI)

p-value

OR (95 % CI)

p-value

OR (95 % CI)

p-value

OR (95 % CI)

p-value

OR (95 % CI)

p-value

OR (95 % CI)

p-value

Screening

 GABRIEL-AS

1.43 (1.18, 1.74)

3.22 × 10−4

1.36 (1.09, 1.70)

6.57 × 10−3

0.54 (0.42, 0.70)

1.51 × 10−6

1.19 (0.99, 1.44)

6.12 × 10−2

1.11 (0.87, 1.42)

3.90 × 10−1

0.78 (0.61, 0.99)

4.12 × 10−2

Follow-up

 BAMSE

0.62 (0.42, 0.91)

1.58 × 10−2

0.55 (0.36, 0.83)

4.12 × 10−3

2.05 (1.26, 3.32)

3.68 × 10−3

0.76 (0.52, 1.10)

1.40 × 10−1

0.60 (0.38, 0.95)

2.99 × 10−2

1.52 (0.99, 2.33)

5.63 × 10−2

 BUSSELTON

0.81 (0.65, 1.02)

6.84 × 10−2

0.78 (0.60, 1.02)

6.55 × 10−2

1.35 (1.03, 1.78)

2.83 × 10−2

0.69 (0.56, 0.87)

1.36 × 10−3

0.63 (0.47, 0.83)

1.28 × 10−3

1.73 (1.31, 2.29)

1.11 × 10−4

 EGEA

0.77 (0.52, 1.14)

1.93 × 10−1

0.88 (0.55, 1.42)

6.01 × 10−1

1.17 (0.68, 2.00)

5.69 × 10−1

0.96 (0.66, 1.38)

8.07 × 10−1

1.04 (0.61, 1.77)

8.84 × 10−1

0.94 (0.57, 1.55)

8.14 × 10−1

 KMSU

1.03 (0.72, 1.47)

8.74 × 10−1

0.96 (0.68, 1.37)

8.35 × 10−1

1.01 (0.66, 1.55)

9.66 × 10−1

0.84 (0.60, 1.17)

3.04 × 10−1

0.72 (0.50, 1.06)

9.45 × 10−2

1.50 (1.02, 2.20)

4.01 × 10−2

 PIAMA

0.89 (0.60, 1.33)

5.78 × 10−1

0.86 (0.55, 1.33)

4.83 × 10−1

1.46 (0.90, 2.37)

1.25 × 10−1

0.65 (0.44, 0.97)

3.67 × 10−2

0.62 (0.37, 1.04)

6.80 × 10−2

2.04 (1.23, 3.40)

5.94 × 10−3

 SAPALDIA

0.91 (0.74, 1.11)

3.63 × 10−1

0.82 (0.64, 1.05)

1.10 × 10−1

1.30 (1.01, 1.69)

4.50 × 10−2

1.04 (0.85, 1.26)

7.27 × 10−1

0.83 (0.63, 1.09)

1.81 × 10−1

1.22 (0.94, 1.57)

1.32 × 10−1

 UFA

0.66 (0.47, 0.91)

1.03 × 10−2

0.62 (0.44, 0.87)

5.46 × 10−3

2.03 (1.35, 3.03)

5.99 × 10−4

0.81 (0.60, 1.09)

1.65 × 10−1

0.68 (0.48, 0.98)

3.61 × 10−2

1.54 (1.05, 2.24)

2.55 × 10−2

Meta-analysis

0.82 (0.74, 0.92)

5.84 × 10−4

0.77 (0.68, 0.88)

6.06 × 10−5

1.40 (1.22, 1.61)

1.58 × 10−6

0.84 (0.75, 0.93)

1.23 × 10−3

0.71 (0.62, 0.82)

1.89 × 10−6

1.45 (1.27, 1.66)

5.78 × 10−8

Heterogeneity

I 2 = 11.2 %; Q = 0.344

I 2 = 9.3 % Q = 0.358

I 2 = 30.8 %, Q = 0.193

I 2 = 37.0 %; Q = 0.146

I 2 = 0.0 %; Q = 0.581

I 2 = 27.1 %; Q = 0.221

Replication

 KARELIA

1.18 (0.57, 2.48)

6.56 × 10−1

1.16 (0.54, 2.47)

7.09 × 10−1

0.58 (0.24, 1.44)

2.41 × 10−1

1.56 (0.76, 3.21)

2.25 × 10−1

0.65 (0.28, 1.55)

3.32 × 10−1

0.93 (0.38, 2.30)

8.80 × 10−1

 

Case-only OR (95 % CI)

Case-only p-value

Case-only OR (95 % CI)

Case-only p-value

 MAS

1.37 (1.01, 1.86)

4.20 × 10−2

0.96 (0.69, 1.34)

8.08 × 10−1

 AUGOSA

1.18 (0.98, 1.42)

7.34 × 10−2

0.99 (0.83, 1.19)

9.42 × 10−1

 SEVERE

0.79 (0.59, 1.07)

1.31 × 10−1

0.75 (0.55, 1.01)

6.10 × 10−2

  1. See the Methods section for model descriptions. Major/minor alleles, respectively, are indicated next to SNP RSIDs. OR: odds ratio. CI: confidence interval. P-value: p-value for the test of the null hypothesis that the respective parameter estimate is equal to zero. Meta-analysis: fixed effects meta-analysis for the follow-up studies. I2: percentage of effect variability due to heterogeneity between studies. Q: p-value from a Q test for heterogeneity. The case-only ORs reflect correlation between alleles of the two SNPs, and the p-value is for the test of the null hypothesis that no such correlation exists. Characteristics of the SNPs are shown in Additional file 1: Tables S6 and S7