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Table 2 Model estimates of interaction between 20p13 and 2q14

From: Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma

  Most significant interaction in the follow-up analysis Most significant interaction in the surrounding region
20p13: rs910652 (T/C) main effect 2q14: rs11684871 (G/A) main effect rs910652 × rs11684871 interaction 20p13: rs1018491 (T/C) main effect 2q14: rs67959717 (G/A) main effect rs1018491× rs67959717 interaction
OR (95 % CI) p-value OR (95 % CI) p-value OR (95 % CI) p-value OR (95 % CI) p-value OR (95 % CI) p-value OR (95 % CI) p-value
Screening
 GABRIEL-AS 1.43 (1.18, 1.74) 3.22 × 10−4 1.36 (1.09, 1.70) 6.57 × 10−3 0.54 (0.42, 0.70) 1.51 × 10−6 1.19 (0.99, 1.44) 6.12 × 10−2 1.11 (0.87, 1.42) 3.90 × 10−1 0.78 (0.61, 0.99) 4.12 × 10−2
Follow-up
 BAMSE 0.62 (0.42, 0.91) 1.58 × 10−2 0.55 (0.36, 0.83) 4.12 × 10−3 2.05 (1.26, 3.32) 3.68 × 10−3 0.76 (0.52, 1.10) 1.40 × 10−1 0.60 (0.38, 0.95) 2.99 × 10−2 1.52 (0.99, 2.33) 5.63 × 10−2
 BUSSELTON 0.81 (0.65, 1.02) 6.84 × 10−2 0.78 (0.60, 1.02) 6.55 × 10−2 1.35 (1.03, 1.78) 2.83 × 10−2 0.69 (0.56, 0.87) 1.36 × 10−3 0.63 (0.47, 0.83) 1.28 × 10−3 1.73 (1.31, 2.29) 1.11 × 10−4
 EGEA 0.77 (0.52, 1.14) 1.93 × 10−1 0.88 (0.55, 1.42) 6.01 × 10−1 1.17 (0.68, 2.00) 5.69 × 10−1 0.96 (0.66, 1.38) 8.07 × 10−1 1.04 (0.61, 1.77) 8.84 × 10−1 0.94 (0.57, 1.55) 8.14 × 10−1
 KMSU 1.03 (0.72, 1.47) 8.74 × 10−1 0.96 (0.68, 1.37) 8.35 × 10−1 1.01 (0.66, 1.55) 9.66 × 10−1 0.84 (0.60, 1.17) 3.04 × 10−1 0.72 (0.50, 1.06) 9.45 × 10−2 1.50 (1.02, 2.20) 4.01 × 10−2
 PIAMA 0.89 (0.60, 1.33) 5.78 × 10−1 0.86 (0.55, 1.33) 4.83 × 10−1 1.46 (0.90, 2.37) 1.25 × 10−1 0.65 (0.44, 0.97) 3.67 × 10−2 0.62 (0.37, 1.04) 6.80 × 10−2 2.04 (1.23, 3.40) 5.94 × 10−3
 SAPALDIA 0.91 (0.74, 1.11) 3.63 × 10−1 0.82 (0.64, 1.05) 1.10 × 10−1 1.30 (1.01, 1.69) 4.50 × 10−2 1.04 (0.85, 1.26) 7.27 × 10−1 0.83 (0.63, 1.09) 1.81 × 10−1 1.22 (0.94, 1.57) 1.32 × 10−1
 UFA 0.66 (0.47, 0.91) 1.03 × 10−2 0.62 (0.44, 0.87) 5.46 × 10−3 2.03 (1.35, 3.03) 5.99 × 10−4 0.81 (0.60, 1.09) 1.65 × 10−1 0.68 (0.48, 0.98) 3.61 × 10−2 1.54 (1.05, 2.24) 2.55 × 10−2
Meta-analysis 0.82 (0.74, 0.92) 5.84 × 10−4 0.77 (0.68, 0.88) 6.06 × 10−5 1.40 (1.22, 1.61) 1.58 × 10−6 0.84 (0.75, 0.93) 1.23 × 10−3 0.71 (0.62, 0.82) 1.89 × 10−6 1.45 (1.27, 1.66) 5.78 × 10−8
Heterogeneity I 2 = 11.2 %; Q = 0.344 I 2 = 9.3 % Q = 0.358 I 2 = 30.8 %, Q = 0.193 I 2 = 37.0 %; Q = 0.146 I 2 = 0.0 %; Q = 0.581 I 2 = 27.1 %; Q = 0.221
Replication
 KARELIA 1.18 (0.57, 2.48) 6.56 × 10−1 1.16 (0.54, 2.47) 7.09 × 10−1 0.58 (0.24, 1.44) 2.41 × 10−1 1.56 (0.76, 3.21) 2.25 × 10−1 0.65 (0.28, 1.55) 3.32 × 10−1 0.93 (0.38, 2.30) 8.80 × 10−1
  Case-only OR (95 % CI) Case-only p-value Case-only OR (95 % CI) Case-only p-value
 MAS 1.37 (1.01, 1.86) 4.20 × 10−2 0.96 (0.69, 1.34) 8.08 × 10−1
 AUGOSA 1.18 (0.98, 1.42) 7.34 × 10−2 0.99 (0.83, 1.19) 9.42 × 10−1
 SEVERE 0.79 (0.59, 1.07) 1.31 × 10−1 0.75 (0.55, 1.01) 6.10 × 10−2
  1. See the Methods section for model descriptions. Major/minor alleles, respectively, are indicated next to SNP RSIDs. OR: odds ratio. CI: confidence interval. P-value: p-value for the test of the null hypothesis that the respective parameter estimate is equal to zero. Meta-analysis: fixed effects meta-analysis for the follow-up studies. I2: percentage of effect variability due to heterogeneity between studies. Q: p-value from a Q test for heterogeneity. The case-only ORs reflect correlation between alleles of the two SNPs, and the p-value is for the test of the null hypothesis that no such correlation exists. Characteristics of the SNPs are shown in Additional file 1: Tables S6 and S7