From: Genome-wide search identifies a gene-gene interaction between 20p13 and 2q14 in asthma
Most significant interaction in the follow-up analysis | Most significant interaction in the surrounding region | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
20p13: rs910652 (T/C) main effect | 2q14: rs11684871 (G/A) main effect | rs910652 × rs11684871 interaction | 20p13: rs1018491 (T/C) main effect | 2q14: rs67959717 (G/A) main effect | rs1018491× rs67959717 interaction | |||||||
OR (95 % CI) | p-value | OR (95 % CI) | p-value | OR (95 % CI) | p-value | OR (95 % CI) | p-value | OR (95 % CI) | p-value | OR (95 % CI) | p-value | |
Screening | ||||||||||||
GABRIEL-AS | 1.43 (1.18, 1.74) | 3.22 × 10−4 | 1.36 (1.09, 1.70) | 6.57 × 10−3 | 0.54 (0.42, 0.70) | 1.51 × 10−6 | 1.19 (0.99, 1.44) | 6.12 × 10−2 | 1.11 (0.87, 1.42) | 3.90 × 10−1 | 0.78 (0.61, 0.99) | 4.12 × 10−2 |
Follow-up | ||||||||||||
BAMSE | 0.62 (0.42, 0.91) | 1.58 × 10−2 | 0.55 (0.36, 0.83) | 4.12 × 10−3 | 2.05 (1.26, 3.32) | 3.68 × 10−3 | 0.76 (0.52, 1.10) | 1.40 × 10−1 | 0.60 (0.38, 0.95) | 2.99 × 10−2 | 1.52 (0.99, 2.33) | 5.63 × 10−2 |
BUSSELTON | 0.81 (0.65, 1.02) | 6.84 × 10−2 | 0.78 (0.60, 1.02) | 6.55 × 10−2 | 1.35 (1.03, 1.78) | 2.83 × 10−2 | 0.69 (0.56, 0.87) | 1.36 × 10−3 | 0.63 (0.47, 0.83) | 1.28 × 10−3 | 1.73 (1.31, 2.29) | 1.11 × 10−4 |
EGEA | 0.77 (0.52, 1.14) | 1.93 × 10−1 | 0.88 (0.55, 1.42) | 6.01 × 10−1 | 1.17 (0.68, 2.00) | 5.69 × 10−1 | 0.96 (0.66, 1.38) | 8.07 × 10−1 | 1.04 (0.61, 1.77) | 8.84 × 10−1 | 0.94 (0.57, 1.55) | 8.14 × 10−1 |
KMSU | 1.03 (0.72, 1.47) | 8.74 × 10−1 | 0.96 (0.68, 1.37) | 8.35 × 10−1 | 1.01 (0.66, 1.55) | 9.66 × 10−1 | 0.84 (0.60, 1.17) | 3.04 × 10−1 | 0.72 (0.50, 1.06) | 9.45 × 10−2 | 1.50 (1.02, 2.20) | 4.01 × 10−2 |
PIAMA | 0.89 (0.60, 1.33) | 5.78 × 10−1 | 0.86 (0.55, 1.33) | 4.83 × 10−1 | 1.46 (0.90, 2.37) | 1.25 × 10−1 | 0.65 (0.44, 0.97) | 3.67 × 10−2 | 0.62 (0.37, 1.04) | 6.80 × 10−2 | 2.04 (1.23, 3.40) | 5.94 × 10−3 |
SAPALDIA | 0.91 (0.74, 1.11) | 3.63 × 10−1 | 0.82 (0.64, 1.05) | 1.10 × 10−1 | 1.30 (1.01, 1.69) | 4.50 × 10−2 | 1.04 (0.85, 1.26) | 7.27 × 10−1 | 0.83 (0.63, 1.09) | 1.81 × 10−1 | 1.22 (0.94, 1.57) | 1.32 × 10−1 |
UFA | 0.66 (0.47, 0.91) | 1.03 × 10−2 | 0.62 (0.44, 0.87) | 5.46 × 10−3 | 2.03 (1.35, 3.03) | 5.99 × 10−4 | 0.81 (0.60, 1.09) | 1.65 × 10−1 | 0.68 (0.48, 0.98) | 3.61 × 10−2 | 1.54 (1.05, 2.24) | 2.55 × 10−2 |
Meta-analysis | 0.82 (0.74, 0.92) | 5.84 × 10−4 | 0.77 (0.68, 0.88) | 6.06 × 10−5 | 1.40 (1.22, 1.61) | 1.58 × 10−6 | 0.84 (0.75, 0.93) | 1.23 × 10−3 | 0.71 (0.62, 0.82) | 1.89 × 10−6 | 1.45 (1.27, 1.66) | 5.78 × 10−8 |
Heterogeneity | I 2 = 11.2 %; Q = 0.344 | I 2 = 9.3 % Q = 0.358 | I 2 = 30.8 %, Q = 0.193 | I 2 = 37.0 %; Q = 0.146 | I 2 = 0.0 %; Q = 0.581 | I 2 = 27.1 %; Q = 0.221 | ||||||
Replication | ||||||||||||
KARELIA | 1.18 (0.57, 2.48) | 6.56 × 10−1 | 1.16 (0.54, 2.47) | 7.09 × 10−1 | 0.58 (0.24, 1.44) | 2.41 × 10−1 | 1.56 (0.76, 3.21) | 2.25 × 10−1 | 0.65 (0.28, 1.55) | 3.32 × 10−1 | 0.93 (0.38, 2.30) | 8.80 × 10−1 |
Case-only OR (95 % CI) | Case-only p-value | Case-only OR (95 % CI) | Case-only p-value | |||||||||
MAS | 1.37 (1.01, 1.86) | 4.20 × 10−2 | 0.96 (0.69, 1.34) | 8.08 × 10−1 | ||||||||
AUGOSA | 1.18 (0.98, 1.42) | 7.34 × 10−2 | 0.99 (0.83, 1.19) | 9.42 × 10−1 | ||||||||
SEVERE | 0.79 (0.59, 1.07) | 1.31 × 10−1 | 0.75 (0.55, 1.01) | 6.10 × 10−2 |