Fig. 2
Locus-specific plot for HLA region corresponding to discovery imputation GWAS results. The –log10 P values (y axis) of the SNPs are shown according to their chromosomal positions (x axis). The estimated recombination rates (cM/Mb) from the HapMap Project (NCBI Build 36) are shown as light blue lines, and the genomic locations of genes within the regions of interest in the NCBI Build 36 human assembly are shown as arrows. SNPs shown in red, orange, green, light blue and blue have r 2 ≥ 0.8, r 2 ≥ 0.6, r 2 ≥ 0.4, r 2 ≥ 0.2 and r 2 < 0.2 with the most highly-associated SNP, respectively. SNPs with no r 2 information with most-highly associated SNP shown in grey. Circles correspond to genotyped SNPs, squares correspond to imputed SNPs. P-values correspond to discovery cohort statistical evidence only; meta-analysis p-values can be found in Table 1 and Additional file 1: Tables S1-S3