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Table 2 HLA Allele Associations from GWAS Discovery

From: Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia

 

Dosage frequencya

Best guess countb

Univariate resultsc

Adjustedd

rs7887e

Allele

Cases

Controls

Cases

Controls

OR (95 % CI)

P

OR (95 % CI) combined

P adjusted

P adjusted

DQA1*01:02

0.22

0.18

703

1725

1.28 (1.15, 1.42)

4.84 × 10−06

1.25 (1.12, 1.39)

5.55 × 10−5

1.56 × 10−4

DQB1*06:02

0.15

0.12

505

1131

1.40 (1.24, 1.58)

6.05 × 10−08

1.34 (1.18, 1.52)

4.84 × 10−6

1.03 × 10−3

DRB1*15:01

0.16

0.12

513

1151

1.37 (1.22, 1.54)

1.29 × 10−07

1.31 (1.16, 1.48)

9.94 × 10−6

9.90 × 10−4

  1. aEstimated allele frequency based on posterior probabilities of allele assignments
  2. bEstimated allele count based on posterior probabilities of allele assignments
  3. cOdds ratio, 95 % Confidence Interval (CI), and P-value based on GWAS cases compared to GWAS controls for each allele alone
  4. dOdds ratio, 95 % Confidence Interval (CI), and P-value based on GWAS cases compared to GWAS controls adjusted for rs7887
  5. e P-value for rs7887 based on GWAS cases compared to GWAS controls adjusted for HLA allele