Skip to main content

Advertisement

Table 2 HLA Allele Associations from GWAS Discovery

From: Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia

  Dosage frequencya Best guess countb Univariate resultsc Adjustedd rs7887e
Allele Cases Controls Cases Controls OR (95 % CI) P OR (95 % CI) combined P adjusted P adjusted
DQA1*01:02 0.22 0.18 703 1725 1.28 (1.15, 1.42) 4.84 × 10−06 1.25 (1.12, 1.39) 5.55 × 10−5 1.56 × 10−4
DQB1*06:02 0.15 0.12 505 1131 1.40 (1.24, 1.58) 6.05 × 10−08 1.34 (1.18, 1.52) 4.84 × 10−6 1.03 × 10−3
DRB1*15:01 0.16 0.12 513 1151 1.37 (1.22, 1.54) 1.29 × 10−07 1.31 (1.16, 1.48) 9.94 × 10−6 9.90 × 10−4
  1. aEstimated allele frequency based on posterior probabilities of allele assignments
  2. bEstimated allele count based on posterior probabilities of allele assignments
  3. cOdds ratio, 95 % Confidence Interval (CI), and P-value based on GWAS cases compared to GWAS controls for each allele alone
  4. dOdds ratio, 95 % Confidence Interval (CI), and P-value based on GWAS cases compared to GWAS controls adjusted for rs7887
  5. e P-value for rs7887 based on GWAS cases compared to GWAS controls adjusted for HLA allele