Fig. 1

Measurements of blood and urine. a Hematologic parameters at 16 weeks of age. The levels of Hb and Ht in ICGN-Chr 2^B6 mice and ICGN-Tns2 ^WT mice were normal. With regard to BUN, no significant difference was observed between ICGN and ICGN-Chr 2^B6 mice, with some ICGN mice but no ICGN-Chr 2^B6 mice showing abnormal BUN levels. b Urinary albumin excretion. Albuminuria was already observed at 4 weeks after birth in ICGN and ICGN-Chr 2^B6 mice. Asterisks indicate P-values for Dunnett’s multiple comparison test, ** <0.01 and * <0.05 vs. ICGN mice (a), or ICGN-Chr 2^B6 mice at the same time point (b) n.s., not significant. Error bars represent standard error. Eleven ICGN mice, four ICGN-Chr 2^B6 mice and three ICGN-Tns2 ^WT mice were analyzed