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Table 3 Top Hispanic and African American SNPs (p < 5 × 10−6) across MESA and WHI a

From: Multiethnic genome-wide association study identifies ethnic-specific associations with body mass index in Hispanics and African Americans

 

MESA Hispanics

WHI Hispanics

SNP

Minor Allele

Chr

Gene

Bp

MAF

beta

95 % CI

pb

MAF

beta

95 % CI

pb

 rs2081325

T

2

intergenic

118,205,061

0.015

3.987

(2.307, 5.667)

3.67 × 10−06

0.009

0.155

(−1.174, 1.483)

0.820

 rs12253976

G

10

KLF6

3,825,732

0.011

5.792

(3.885, 7.698)

3.43 × 10−09

0.008

0.598

(−0.837, 2.032)

0.414

 rs1409874

T

10

intergenic

6,690,432

0.322

−1.045

(−1.488, −0.602)

4.22 × 10−06

0.312

−0.089

(−0.380, 0.202)

0.550

 rs1249269

G

10

intergenic

28,660,149

0.414

1.030

(0.635, 1.425)

3.79 × 10−07

0.410

−0.197

(−0.472, 0.077)

0.159

 rs11007044

A

10

intergenic

28,680,671

0.171

1.290

(0.772, 1.808)

1.19 × 10−06

0.176

−0.113

(−0.465, 0.239)

0.530

  rs12255372

T

10

TCF7L2

114,798,892

0.244

−1.111

(−1.578, −0.645)

3.33 × 10−06

0.249

−0.304

(−0.613, 0.006)

0.054

 rs16943469

T

17

YPEL2

54,799,958

0.015

3.984

(2.362, 5.607)

1.68 × 10−06

0.006

0.229

(−1.475, 1.932)

0.793

 rs6038725

A

20

intergenic

7,081,039

0.426

−1.038

(−1.429, −0.647)

2.24 × 10−07

0.384

0.218

(−0.054, 0.489)

0.116

 rs179747

G

20

intergenic

7,107,995

0.444

−1.065

(−1.455, −0.676)

1.01 × 10−07

0.392

0.228

(−0.044, 0.501)

0.101

 rs6085916

G

20

intergenic

7,112,725

0.451

−1.028

(−1.416, −0.641)

2.28 × 10−07

0.399

0.197

(−0.078, 0.472)

0.160

 rs2326897

C

20

intergenic

7,112,922

0.449

−1.051

(−1.439, −0.662)

1.39 × 10−07

0.397

0.197

(−0.073, 0.467)

0.153

 rs13036410

T

20

intergenic

7,122,578

0.445

−1.047

(−1.433, −0.661)

1.29 × 10−07

0.391

0.219

(−0.050, 0.488)

0.111

     

MESA African Americans

WHI African Americans

SNP

Minor Allele

Chr

Gene

Bp

MAF

beta

95 % CI

pb

MAF

beta

95 % CI

pb

 rs7602754

C

2

intergenic

19,315,168

0.356

−0.956

(−1.362, −0.549)

4.41 × 10−06

0.340

0.099

(−0.117, 0.315)

0.370

  rs6435678

C

2

ERBB4

212,418,713

0.231

1.104

(0.643, 1.564)

2.85 × 10−06

0.235

0.232

(−0.009, 0.476)

0.061

  rs6739663

A

2

intergenic

240,878,904

0.499

−0.926

(−1.319, −0.532)

4.45 × 10−06

0.494

−0.194

(−0.399, 0.008)

0.062

 rs7763896

C

6

CTGF

132,321,497

0.026

3.140

(1.927, 4.352)

4.35 × 10−07

0.026

−0.175

(−0.806, 0.460)

0.589

 rs1567101

A

10

intergenic

30,901,089

0.386

1.030

(0.627, 1.433)

5.96 × 10−07

0.392

0.033

(−0.178, 0.242)

0.761

 rs7092615

T

10

intergenic

30,902,186

0.375

1.025

(0.619, 1.431)

8.36 × 10−07

0.386

0.061

(−0.149, 0.271)

0.567

 rs12826956

G

12

intergenic

73,122,021

0.150

1.300

(0.753, 1.847)

3.48 × 10−06

0.152

0.010

(−0.277, 0.292)

0.945

 rs2822787

A

21

SAMSN1

14,876,531

0.215

1.153

(0.670, 1.636)

3.12 × 10−06

0.202

−0.067

(−0.318, 0.186)

0.601

  1. Abbreviations: Chr Chromosome, Bp base pair, CI confidence interval, MAF minor allele frequency
  2. a Bolded SNPs have beta in the same direction and suggestive p-values in MESA and WHI
  3. b p-values adjusted for all ethnic-specific linear regression model covariates; only the MESA analyses are sex-adjusted
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BMC Genomic Data

ISSN: 2730-6844

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