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Table 1 Association of 15 functional SNPs in eight candidate genes with atorvastatin-induced liver injury

From: ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population

Gene SNP Allele (1/2) Amino acid change Other name AILIa Non-AILIa RAF P valueb HWE
      11 12 22 11 12 22 AILI Non-AILI ALLELIC DOM REC AILI Non-AILI
ABCB1 rs1045642 C/T I1145I C3435T 12 15 3 151 196 67 0.65 0.60 0.50 0.70 0.60 0.59 0.80
  rs2032582 T, A/G S,T893A G2677 T/A 2 16 12 138 191 85 0.67 0.44 0.00068 0.0017 0.020 0.27 0.21
   G, A/T A,T893S   15 14 1 158 193 63 0.73 0.61 0.073 0.24 0.10 0.29 0.75
   G, T/A A,S893T   26 4 0 283 114 17 0.93 0.82 0.031 0.039 0.62 0.70 0.21
  rs1128503 T/C G412G C1236T 15 12 3 146 197 71 0.70 0.59 0.10 0.12 0.45 0.79 0.74
ABCG2 rs2231142 C/A Q141K C421A 12 15 3 195 180 39 0.35 0.31 0.57 0.57 0.76 0.59 0.78
CYP2C9 rs1799853 C/T R144C CYP2C9*2 30 0 0 412 0 0 1.00 1.00 1.00 1.00 1.00 1.00 1.00
  rs1057910 A/C I359L CYP2C9*3 28 2 0 393 20 0 0.03 0.02 0.66 0.65 1.00 0.85 0.61
CYP2C19 rs4244285 G/A P227P CYP2C19*2 16 9 5 197 180 36 0.32 0.31 0.88 0.58 0.18 0.09 0.57
  rs4986893 G/A W212X CYP2C19*3 27 3 0 321 86 6 0.95 0.88 0.14 0.16 1.00 0.77 0.93
CYP3A4 rs12721627 C/G T185S CYP3A4*16 29 1 0 405 8 0 0.02 0.01 0.47 0.47 1.00 0.93 0.84
  rs28371759 T/C L292P CYP3A4*18 29 1 0 399 14 0 0.98 0.98 1.00 1.00 1.00 0.93 0.73
CYP3A5 rs776746 G/A CYP3A5*3 18 11 1 223 165 26 0.78 0.74 0.54 0.57 1.00 0.66 0.54
SLCO1B1 rs2306283 G/A N130D SLCO1B1*1B 14 12 4 185 179 50 0.67 0.66 1.00 0.85 0.77 0.58 0.51
  rs4149056 T/C V174A SLCO1B1*5 18 11 1 306 95 13 0.22 0.15 0.14 0.13 1.00 0.66 0.10
UGT1A1 rs4148323 G/A G71R UGT1A1*6 25 5 0 281 118 15 0.92 0.82 0.075 0.10 0.61 0.62 0.55
  rs8175347 (TA)6/(TA)7 UGT1A1*28 23 7 0 332 76 6 0.12 0.11 0.83 0.64 1.00 0.47 0.49
  1. Abbreviation: AILI atorvastatin-induced liver injury, RAF risk allele frequency, ALLELIC Allelic model, Dom Dominant model, REC Recessive model, HWE Hardy–Weinberg equilibrium
  2. aAILI, N = 30; Non-AILI, N = 414
  3. bThe lowest significant P value after Bonferroni correction among three models is shown in bold (P < 0.0011)