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Table 2 Association of haplotypes consisting of three SNPs of ABCB1 with atorvastatin-induced liver injury

From: ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population

rs1128503

rs2032582

rs1045642

Number of carriers

P valueb

   

AILIa (%)

Non-AILIa (%)

 

T

T

T

15 (50.0)

237 (57.2)

0.45

C

G

C

11 (36.7)

158 (38.2)

1.00

T

G

C

16 (53.3)

126 (30.4)

0.014

C

A

C

4 (13.3)

128 (30.9)

0.060

T

G

T

3 (10.0)

25 (6.0)

0.45

T

T

C

0 (0.0)

24 (5.8)

0.39

C

G

T

2 (6.7)

11 (2.7)

0.22

T

A

C

0 (0.0)

5 (1.2)

1.00

C

T

T

0 (0.0)

2 (0.5)

1.00

C

T

C

0 (0.0)

2 (0.5)

1.00

  1. Abbreviation: AILI atorvastatin-induced liver injury
  2. aAILI, N = 30; Non-AILI, N = 414
  3. bThe significant P value after Bonferroni correction is less than 0.005