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Table 3 Atorvastatin-dependent cytotoxicity in Flp-In-293 cells stably expressing different ABCB1 proteins

From: ABCB1 polymorphism is associated with atorvastatin-induced liver injury in Japanese population

Cell name ABCB1   IC50 (mM) P value
  Allele Amino acid Mean ± SE  
Mock 2.74 ± 0.04
2677G wild-type G Alanine 5.44 ± 0.10
2677 T T Serine 6.02 ± 0.07 0.009
2677A A Threonine 5.95 ± 0.08 0.026
  1. Abbreviation: SE standard error, CI confidence interval
  2. Experiments were performed in duplicate wells and repeated four times. The significant P value is shown in bold (P < 0.05, versus 2677G wild-type, one-way analysis of variance with Dunnett’s post-hoc test)