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Fig. 2 | BMC Genetics

Fig. 2

From: Repetitive element hypermethylation in multiple sclerosis patients

Fig. 2

Methylation levels of Alu, LINE-1 and SAT-α in MS patients, grouped by Expanded Disability Status Scale (EDSS), are represented as box plots. Data were adjusted for age, sex and smoking habit. All groups had a similar number of individuals: 18 participants for ‘EDSS = 1.0’, 17 for ‘1.5 ≤ EDSS ≤ 2.5’ and 15 for ‘3.0 ≤ EDSS ≤ 7.5’. For both Alu and LINE-1 the highest EDSS group (the reference) was significantly different from the lower two groups. An absolute difference in methylation of 0.47 %5mC can be observed for ‘EDSS = 1’ (p = 0.034) and 0.63 %5mC for ‘1.5 ≤ EDSS ≤ 2.5’ (p = 0.007) compared with the reference group for Alu. In LINE-1, methylation decreased with 0.95 %5mC for ‘EDSS = 1’ (p = 0.050) and 1.07 % for ‘1.5 ≤ EDSS ≤ 2.5’ (p = 0.033) compared to the reference group. * p < 0.05

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