From: Repetitive element hypermethylation in multiple sclerosis patients
Characteristics | MS patients | Healthy controls | p-value |
---|---|---|---|
n = 51 | n = 137 | ||
Age (years) | |||
Mean ± SD | 39.6 ± 8.1 | 41.4 ± 9.1 | >0.1 |
Gender | |||
Female | 38 (74.5) | 100 (73.0) | >0.1 |
Male | 13 (25.5) | 37 (27.0) | - |
Smoking habita | |||
Yes | 15 (35.3) | 52 (38.0) | >0.1 |
No | 33 (64.7) | 85 (62.0) | - |
Neurological episodes | |||
Only one | 30 (58.8) | - | |
At least two | 21 (41.2) | - | |
Disabilityb | |||
EDSS = 1.0 | 18 (36.0) | - | |
1.5 ≤ EDSS ≤ 2.5 | 17 (34.0) | - | |
3.0 ≤ EDSS ≤ 7 | 15 (30.0) | - | |
Onset of MS | |||
1981 – 1999 | 18 (35.3) | - | |
2000 – 2004 | 15 (29.4) | - | |
2005 – 2010 | 18 (35.3) | - | |
Multisystem deficits at onset | |||
Yes | 14 (27.5) | - | |
No | 37 (72.5) | - | |
Oligoclonal Bands in CSFc | |||
Yes | 44 (89.8) | - | |
No | 5 (10.2) | - | |
Methylation markers (%5mC) | |||
Alu d | 25.3 ± 0.6 | 24.5 ± 1.1 | <0.001 |
LINE-1 | 85.1 ± 1.4 | 82.6 ± 2.8 | <0.001 |
SAT- α | 80.3 ± 2.6 | 78.9 ± 2.8 | 0.014 |