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Table 2 The genotyping data on rs1799945 (H63D), rs1800730 (S65C), rs1800562 (C282Y), rs2071303, rs1800708, and rs1572982 of the HFE gene in Northern Asian populations and in some groups of patients. MS + AG: metabolic syndrome associated with arterial hypertension, T2DM: type 2 diabetes mellitus

From: Haplotype analysis of the HFE gene among populations of Northern Eurasia, in patients with metabolic disorders or stomach cancer, and in long-lived people

Exon SNPs

Intron SNPs

Caucasoids

Patients

Long-lived people

Tatars

Asians

Russian adolescents

Russian old believers (an isolate)

Germans

MS + AH total

MS + AH men

MS + AH women

Fatty liver disease

T2DM

Stomach cancer

total

men

women

Shorians

Khakas

Yukaghirs

Koryaks

Nivkhs

Evenks

Nanaians

Yakuts

Eskimos

C282Y/C282Y

TTG/TTG

0

0

0

0

0

0

1

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

H63D/H63D

CTA/CTA

10

0

1

1

0

1

1

4

5

7

1

6

1

0

0

0

0

0

0

0

0

0

H63D/S65C

CTA/CCA

1

0

0

1

1

0

0

0

0

0

0

0

1

0

1

0

0

0

0

0

0

0

C282Y/H63D

TTG/CTA

4

0

1

1

1

0

1

1

2

1

0

1

0

0

1

0

0

0

0

0

0

0

C282Y/WT

TTG/TTG

9

3

3

10

5

5

2

3

1

3

1

2

0

0

0

4

0

0

0

0

0

0

TTG/TTA

3

0

0

7

1

6

0

0

1

2

1

1

0

1

0

0

0

0

0

0

0

0

TTG/CTA

0

2

0

2

2

0

1

2

2

1

0

1

0

0

0

0

0

0

0

0

0

0

TTG/CCA

0

2

0

1

0

1

0

0

0

2

0

2

0

0

0

1

0

0

0

0

0

0

H63D/WT

CTA/CCA

11

0

1

10

0

10

1

1

2

8

1

7

1

8

0

4

2

3

0

0

0

0

CTA/CTA

18

4

3

5

3

2

3

6

3

7

1

6

0

1

1

0

1

0

0

1

0

0

CTA/TTA

12

4

5

14

5

9

3

6

2

4

1

3

4

5

1

0

0

0

0

0

1

0

CTA/TTG

52

13

16

50

19

31

7

22

21

29

8

21

12

6

5

3

0

0

2

4

0

0

S65C/WT

CCA/CTA

2

1

0

1

1

0

0

0

0

0

0

0

0

1

2

0

0

0

0

0

0

0

CCA/CCA

0

1

1

0

0

0

0

1

0

0

0

0

0

1

0

1

1

0

0

0

0

0

CCA/TTG

5

0

3

6

4

2

4

4

2

1

0

1

5

1

0

0

0

0

0

0

0

0

CCA/TTA

2

2

0

1

1

0

1

1

0

1

0

1

1

2

1

1

0

0

0

0

0

0

WT/WT

TTG/TTG

77

26

14

104

39

65

19

54

44

75

12

63

54

28

17

18

5

2

5

5

9

6

TTG/TTA

54

18

7

46

10

36

11

12

21

33

13

20

26

10

11

5

2

0

3

0

5

5

CCA/CCA

3

1

0

6

3

3

1

2

2

2

0

2

5

11

8

10

17

9

10

2

2

8

CCA/CTA

5

3

0

5

2

3

0

1

6

1

0

1

11

12

2

1

7

1

1

9

0

2

CTA/CTA

4

0

2

2

1

1

0

1

5

1

0

1

2

2

2

0

0

0

0

2

0

0

CTA/TTA

16

2

1

10

1

9

0

5

5

9

2

7

7

4

2

2

0

0

0

0

0

1

TTA/TTA

4

2

0

8

4

4

0

1

3

4

0

4

5

6

4

0

1

0

0

0

0

3

TTG/CTA

27

6

19

39

19

20

11

15

13

27

6

21

14

5

3

3

4

0

2

0

1

1

CCA/TTA

7

3

0

11

2

9

2

2

3

9

2

7

10

9

10

7

4

4

1

1

5

5

TTG/CCA

30

9

3

28

9

19

5

11

7

27

5

22

37

29

14

21

37

10

14

9

8

11

Total

 

356

102

80

369

133

236

74

155

150

254

54

200

196

142

85

81

81

29

38

33

31

42