Fig. 2

Interaction graph generated through Multifactor Dimensionality Reduction (MDR) software. a Population based analysis for male subjects; b Population based analysis for female subjects. The graphical interaction model describe the percentage of entropy (i.e. information gain or IG) in case-control status that is explained by each factor (i.e. gene variant) or two-way interaction. Two-way interactions between factors are depicted by line accompanied by a percent of entropy explained by that interaction. Values inside large boxes on nodes indicate information gain (IG) of individual/independent main effect of each polymorphic variant, whereas values inside small boxes between nodes exemplify IG of pairwise combination/interactive effects of respective variants. Positive IG values, between the nodes, indicate the synergistic interactions; whereas negative IG values indicate the redundancy between the respective nodes/variants. Schematic coloration represents a continuum from synergy to redundancy. The red lines represent a high degree of synergy. The orange lines represent moderate synergy. The golden yellow lines accompanied by a positive percent of entropy represent minimal synergy, whereas the golden yellow lines accompanied by a negative percent of entropy represent minimal redundancy. Green line represents high redundancy