Table 3 Results of final testing using simulated variants
MLH1 | Variant type | ||
Pathogenic | Benign | ||
 HWA Call | Pathogenic | 25162 | 17 |
Benign | 61 | 50150 | |
No Call | 277 | 333 | |
 Total Trials | 25500 | 50500 | |
 PPV | 0.9989 | ||
 NPV | 0.9992 | ||
MSH2 | Variant Type | ||
Pathogenic | Benign | ||
 HWA Call | Pathogenic | 24904 | 29 |
Benign | 69 | 50306 | |
No Call | 527 | 165 | |
 Total Trials | 25500 | 50500 | |
 PPV | 0.9971 | ||
 NPV | 0.9995 | ||
MSH6 | Variant Type | ||
Pathogenic | Benign | ||
 HWA Call | Pathogenic | 25038 | 6 |
Benign | 23 | 50322 | |
No Call | 439 | 172 | |
 Total Trials | 25500 | 50500 | |
 PPV | 0.9992 | ||
 NPV | 0.9999 | ||