Table 4 Testing results for true variants (100 trials per variant)
MLH1 | Variant type | ||
Pathogenic | Benign | ||
 HWA Call | Pathogenic | 4890 | 2 |
Benign | 7 | 4328 | |
No Call | 1403 | 1370 | |
 Total Trials | 6300 | 5700 | |
 PPV | 0.9986 | ||
 NPV | 0.9995 | ||
MSH2 | Variant Type | ||
Pathogenic | Benign | ||
 HWA Call | Pathogenic | 2877 | 1 |
Benign | 1 | 5388 | |
No Call | 822 | 2011 | |
 Total Trials | 3700 | 7400 | |
 PPV | 0.9991 | ||
 NPV | 0.9999 | ||
MSH6 | Variant Type | ||
Pathogenic | Benign | ||
 HWA Call | Pathogenic | 1906 | 1 |
Benign | 0 | 6955 | |
No Call | 1694 | 4244 | |
 Total Trials | 3600 | 11200 | |
 PPV | 0.9989 | ||
 NPV | 100.0000 | ||