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Table 3 Genotype and allele frequencies of rs895819, rs11614913, rs6505162, rs4919510, and rs2682818 by number of BC cases per family, in BRCA1/2-negative breast cancer cases and controls

From: Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population

  

Families with 2 BC and/or OC cases (n = 148)

Families with ≥3 BC and/or OC cases (n = 121)

Genotype or allele

Controls (%) (n = 807)

BC cases (%)

p-valuea

OR [95 % CI]

BC cases (%)

p-valuea

OR [95 % CI]

rs895819 (Pre-miR 27a)

 A/A

432 (53 %)

83 (56 %)

-

1.0 (Ref)

63 (52 %)

-

1.0 (Ref)

 A/G

298 (37 %)

60 (41 %)

0.8

1.0 [0.7–1.5]

45 (37 %)

0.9

1.0 [0.6–1.5]

 G/G

77 (10 %)

5 (3 %)

0.01

0.3 [0.1–0.8]

13 (11 %)

0.6

1.1 [0.6–2.2]

 A/G + G/G

375 (47 %)

65 (44 %)

0.5

0.9 [0.6–1.2]

58 (48 %)

0.7

1.0 [0.7–1.5]

 Allele A

1162 (0.72)

226 (0.76)

-

1.0 (Ref)

171 (0.71)

-

1.0 (Ref)

 Allele G

452 (0.28)

70 (0.24)

0.1

0.7 [0.5–1.0]

71 (0.29)

0.7

1.0 [0.7–1.4]

rs6505162 (Pre-miR 423)

 C/C

284 (35 %)

41 (28 %)

-

1.0 (Ref)

33 (27 %)

-

1.0 (Ref)

 C/A

385 (48 %)

81 (55 %)

0.07

1.4 [0.9–2.2]

60 (50 %)

0.2

1.3 [0.8–2.1]

 A/A

138 (17 %)

26 (17 %)

0.3

1.3 [0.8–2.2]

28 (23 %)

0.05

1.7 [1.0–2.0]

 C/A + A/A

523 (65 %)

107 (72 %)

0.08

1.4 [1.0–2.1]

88 (73 %)

0.09

1.4 [0.9–2.2]

 Allele C

953 (0.59)

163 (055)

-

1.0 (Ref)

126 (0.52)

-

1.0 (Ref)

 Allele A

661 (0.41)

133 (0.45)

0.2

1.2 [0.9–1.5]

116 (0.48)

0.04

1.3 [1.0–1.7]

rs2682818 (Pre-miR 618)

 C/C

699 (86.6 %)

120 (81 %)

-

1.0 (Ref)

101 (83.5 %)

-

1.0 (Ref)

 C/A

102 (12.6 %)

26 (18 %)

0.1

1.3 [0.9–2.3]

19 (15.7 %)

0.3

1.3 [0.7–2.2]

 A/A

6 (0.7 %)

2 (1 %)

0.3

1.9 [0.3–9.7]

1 (0.8 %)

1.0

1.1 [0.1–9.6]

 C/A + A/A

108 (13.3 %)

28 (19 %)

0.09

1.5 [1.0–2.5]

20 (16.5 %)

0.3

1.2 [0.7–2.1]

 Allele C

1500 (0.93)

266 (0.90)

-

1.0 (Ref)

221 (0.91)

-

1.0 (Ref)

 Allele A

114 (0.07)

30 (0.10)

0.07

1.4 [0.9–2.2]

21 (0.09)

0.3

1.2 [0.7–2.0]

  1. BC breast cancer, OC ovarian cancer, OR odds ratio, CI confidence interval
  2. aFisher’s exact test
  3. Bold values are statistically significant (p < 0.05)