|  | Families with 2 BC and/or OC cases (n = 148) | Families with ≥3 BC and/or OC cases (n = 121) | ||||
---|---|---|---|---|---|---|---|
Genotype or allele | Controls (%) (n = 807) | BC cases (%) | p-valuea | OR [95 % CI] | BC cases (%) | p-valuea | OR [95 % CI] |
rs895819 (Pre-miR 27a) | |||||||
 A/A | 432 (53 %) | 83 (56 %) | - | 1.0 (Ref) | 63 (52 %) | - | 1.0 (Ref) |
 A/G | 298 (37 %) | 60 (41 %) | 0.8 | 1.0 [0.7–1.5] | 45 (37 %) | 0.9 | 1.0 [0.6–1.5] |
 G/G | 77 (10 %) | 5 (3 %) | 0.01 | 0.3 [0.1–0.8] | 13 (11 %) | 0.6 | 1.1 [0.6–2.2] |
 A/G + G/G | 375 (47 %) | 65 (44 %) | 0.5 | 0.9 [0.6–1.2] | 58 (48 %) | 0.7 | 1.0 [0.7–1.5] |
 Allele A | 1162 (0.72) | 226 (0.76) | - | 1.0 (Ref) | 171 (0.71) | - | 1.0 (Ref) |
 Allele G | 452 (0.28) | 70 (0.24) | 0.1 | 0.7 [0.5–1.0] | 71 (0.29) | 0.7 | 1.0 [0.7–1.4] |
rs6505162 (Pre-miR 423) | |||||||
 C/C | 284 (35 %) | 41 (28 %) | - | 1.0 (Ref) | 33 (27 %) | - | 1.0 (Ref) |
 C/A | 385 (48 %) | 81 (55 %) | 0.07 | 1.4 [0.9–2.2] | 60 (50 %) | 0.2 | 1.3 [0.8–2.1] |
 A/A | 138 (17 %) | 26 (17 %) | 0.3 | 1.3 [0.8–2.2] | 28 (23 %) | 0.05 | 1.7 [1.0–2.0] |
 C/A + A/A | 523 (65 %) | 107 (72 %) | 0.08 | 1.4 [1.0–2.1] | 88 (73 %) | 0.09 | 1.4 [0.9–2.2] |
 Allele C | 953 (0.59) | 163 (055) | - | 1.0 (Ref) | 126 (0.52) | - | 1.0 (Ref) |
 Allele A | 661 (0.41) | 133 (0.45) | 0.2 | 1.2 [0.9–1.5] | 116 (0.48) | 0.04 | 1.3 [1.0–1.7] |
rs2682818 (Pre-miR 618) | |||||||
 C/C | 699 (86.6 %) | 120 (81 %) | - | 1.0 (Ref) | 101 (83.5 %) | - | 1.0 (Ref) |
 C/A | 102 (12.6 %) | 26 (18 %) | 0.1 | 1.3 [0.9–2.3] | 19 (15.7 %) | 0.3 | 1.3 [0.7–2.2] |
 A/A | 6 (0.7 %) | 2 (1 %) | 0.3 | 1.9 [0.3–9.7] | 1 (0.8 %) | 1.0 | 1.1 [0.1–9.6] |
 C/A + A/A | 108 (13.3 %) | 28 (19 %) | 0.09 | 1.5 [1.0–2.5] | 20 (16.5 %) | 0.3 | 1.2 [0.7–2.1] |
 Allele C | 1500 (0.93) | 266 (0.90) | - | 1.0 (Ref) | 221 (0.91) | - | 1.0 (Ref) |
 Allele A | 114 (0.07) | 30 (0.10) | 0.07 | 1.4 [0.9–2.2] | 21 (0.09) | 0.3 | 1.2 [0.7–2.0] |