Genetic analysis of variation in lifespan using a multiparental advanced intercross Drosophila mapping population

Table 2 FlyBase aging candidate genes within mapped QTL

QTL ^a	Gene name	Symbol
Q1 ^b	cabeza	caz
	hangover	hang
	methuselah-like 1	mthl1
Q2	carnation	car
	CG18809	–
	domeless	dome ^c
	Ubiquilin	Ubqn ^c
	Zwischenferment	Zw ^c
Q3	Cystathionine beta-synthase	Cbs
Q3	Microsomal glutathione S-transferase-like	Mgstl
Q4	Coenzyme Q biosynthesis protein 2	Coq2
	Insulator binding factor 2	Ibf2
	pumilio	pum
	Relish	Rel ^c

^a No genes from our FlyBase controlled vocabulary searches were present within the Q5 interval
^b The gene CG32576, which resides within Q1, was also tagged in our FlyBase search as “short lived” but this appears to be an annotation error [66]
^c These genes were also shown to increase in expression with age in female heads in our RNAseq study

ISSN: 2730-6844